1. Anti-infection Protein Tyrosine Kinase/RTK
  2. Bacterial c-Met/HGFR Antibiotic
  3. Meleagrin

Meleagri 是由青霉属 (Penicillium) 真菌产生的具有抗微生物和抗增殖活性的罗奎福汀 C 衍生生物碱。Meleagrin 是一类 FabI 抑制剂。Meleagri 是一种主要的 c-Met 抑制实体,有助于控制 c-Met 依赖性转移和侵袭性乳腺癌。

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Meleagrin Chemical Structure

Meleagrin Chemical Structure

CAS No. : 71751-77-4

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Meleagrin is a roquefortine C-derived alkaloid produced by fungi of the genus Penicillium and has antimicrobial and anti-proliferative activities. Meleagrin is a class of FabI inhibitor. Meleagrin is a lead c-Met inhibitory entity useful for the control of c-Met-dependent metastatic and invasive breast malignancies[1][2][3].

体外研究
(In Vitro)

Meleagrin inhibits the growth of the human breast cancer cell lines MDA-MB-231, MDA-468, BT-474, SK BR-3, MCF7 and MCF7-dox[3].
Meleagrin causes a dose-dependent inhibition of HGF-induced cell migration, and invasion of breast cancer cell lines[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Meleagrin potently suppresses the invasive triple negative breast tumor cell growth in an orthotopic athymic nude mice model[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

433.46

Formula

C23H23N5O4

CAS 号
性状

固体

颜色

Off-white to light yellow

结构分类
初始来源

marine fungus Emericella dentata Nq45

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥99.0%

参考文献
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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Meleagrin
目录号:
HY-N6797
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