2. Metabolic Enzyme/Protease Apoptosis
  3. Proteasome Apoptosis
  4. MG-101

MG-101  (Synonyms: Calpain inhibitor I; Ac-LLnL-CHO; ALLN)

目录号: HY-18964G
产品使用指南 技术支持

MG-101 (GMP) (Calpain inhibitor I (GMP)) 是 GMP 级别的 MG-101 (HY-18964) 。GMP 级别的小分子可用做细胞疗法中的辅助试剂。MG-101 (ALLN) 是 半胱氨酸蛋白酶 的抑制剂，抑制钙蛋白酶 I，钙蛋白酶 II，组织蛋白酶 B 和组织蛋白酶 L，其 Ki 值分别为 190，220，150 和 500 pM。MG-101 诱导细胞凋亡 (apoptosis)，抑制结肠肿瘤生长，可用于结肠癌的研究。

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MG-101 Chemical Structure

MG-101 Chemical Structure

CAS No. : 110044-82-1

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MG-101 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MG-101 (GMP) (Calpain inhibitor I (GMP)) is MG-101 (HY-18964) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer[1].

体外研究
(In Vitro)

MG-101 (GMP) (0-26 μM；24 h) 影响结肠癌HCT116细胞的生长[1]。
MG-101 (GMP) (0-26 μM；24 h) 诱导细胞凋亡多种癌细胞[1]。
MG-101 (GMP) (0-26 μM；24 h) 诱导 HCT116 细胞发生 Bax 依赖性细胞凋亡[1]。 HCT116, RKO, SW480 and HepG2 cell lines 0-26 μM 24 hours Dose-dependently decreased the concentration of pro-caspase 3 and increased the concentration of cleaved-PARP in HCT116 cells. Induced apoptosis of HCT116, RKO, SW480 and HepG2 cells. HCT116, HCT116/p53-/- and HCT116/Bax-/- cell lines Induced apoptosis via a Bax-dependent manner, but not via a p53-dependent manner.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MG-101 相关抗体:

Cell Viability Assay[1]

Cell Line: HCT116 cell line
Concentration: 0-26 μM
Incubation Time: 24 hours
Result: Anchorage-independently and significantly decreased the viability of HCT116 cells.

Western Blot Analysis[1]

Cell Line: HCT116, RKO, SW480 and HepG2 cell lines
Concentration: 0-26 μM
Incubation Time: 24 hours
Result: Dose-dependently decreased the concentration of pro-caspase 3 and increased the concentration of cleaved-PARP in HCT116 cells. Induced apoptosis of HCT116, RKO, SW480 and HepG2 cells.

Western Blot Analysis[1]

Cell Line: HCT116, HCT116/p53-/- and HCT116/Bax-/- cell lines
Concentration: 0-26 μM
Incubation Time: 24 hours
Result: Induced apoptosis via a Bax-dependent manner, but not via a p53-dependent manner.
体内研究
(In Vivo)

MG-101 (GMP) (10 mg/kg；ip 每天一次，持续 15 天) 抑制裸鼠体内的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice with HCT116 cells injection[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; 10 mg/kg once daily; for 15 days
Result: Significantly decreased tumor weight and volume of treated mice at day 26 compared to control mice, and showed no effect on body weights.
分子量

383.53

Formula

C20H37N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MG-101 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MG-101 (GMP)110044-82-1Calpain inhibitor I (GMP)Ac-LLnL-CHO (GMP)ALLN (GMP)ProteasomeApoptosisInhibitorinhibitorinhibit

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