1. Immunology/Inflammation
  2. CD74
  3. Milatuzumab

Milatuzumab  (Synonyms: hLL1; MEDI-115)

目录号: HY-P99731 纯度: 99.39%
COA

Milatuzumab (hLL1; MEDI-115) 是一种人源化抗 CD74 单克隆抗体。CD74 是一种完整的膜蛋白,与促进 B 细胞生长和存活有关。Milatuzumab 导致自由基氧的产生和线粒体膜电位的丧失。 Milatuzumaba 还降低 CD20/CD74 聚集体和细胞粘附,从而导致细胞死亡。

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Milatuzumab Chemical Structure

Milatuzumab Chemical Structure

CAS No. : 899796-83-9

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Milatuzumab (hLL1; MEDI-115) is a humanized anti-CD74 monoclonal antibody. CD74, a integral membrane protein, is associated with the promotion of B-cell growth and survival. Milatuzumab causes free radical oxygen generation, and loss of mitochondrial membrane potential. Milatuzumaba also decreases CD20/CD74 aggregates and cell adhesion, to lead to cell death[1].

IC50 & Target

CD74[1]

体外研究
(In Vitro)

Milatuzumaba(5 μg/mL;8-48 小时)增强 MCL 细胞系和原发性患者肿瘤细胞的细胞死亡[1]
Milatuzumaba(5 μg/mL;0.5-2 h)在 Jeko、Mino 和 SP-53 细胞中介导细胞毒性,部分取决于 ROS 的产生和线粒体跨膜电位的丧失[1]
Milatuzumaba(5 μg/mL;4 小时)抑制 NF-κB 通路并诱导细胞凋亡,凋亡机制与 caspase 裂解、Bcl-2 家族成员失调或诱导自噬无关[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Jeko and Mino cells
Concentration: 5 μg/mL
Incubation Time: 4 hours
Result: Insignificant down-regulation of antiapoptotic proteins, such as Bax, Bcl-2, Bcl-xL, and Mcl-1.

Cell Viability Assay[1]

Cell Line: MCL cell lines and primarypatient tumor cells
Concentration: 5 μg/mL
Incubation Time: 8, 24, and 48 hours
Result: Resulted in cell death of Jeko, Mino, SP-53, Rec-1, HBL-2, and Granta cells.

Immunofluorescence[1]

Cell Line: Jeko, Mino, and SP-53 cells
Concentration: 5 μg/mL; with or without 10 mM N-acetylcysteine (HY-B0215) for 1.5 h
Incubation Time: 0.5, 1, 1.5, and 2 hours
Result: Increased ROS generation as early as 0.5 hours, while peaking at 1 to 1.5 hours and reducing at 2 hours.Therefore, it resulted cell death, but reserved by nonspecific ROS scavenger.
体内研究
(In Vivo)

Milatuzumaba(15 mg/kg/天;腹腔注射;每 3 天一次)显着提高携带 Jeko 癌细胞的雌性 SCID 小鼠的存活率。并且Milatuzumaba与Rituximab (HY-P9913) 在该小鼠模型中具有协同作用[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Jeko mouse model[1]
Dosage: 15 mg/kg/day; with or without 15 mg/kg Rituximab
Administration: Intraperitoneal injection; once every 3 days, starting at day 15 after engraftment
Result: Resulted the mean survival for the combination treated group of 44.5 days, compared with 33.5 days for Milatuzumaba treated, 28 days for control.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

纯度: 99.39%

参考文献

Milatuzumab 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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