1. Apoptosis
  2. Apoptosis
  3. (Rac)-Idroxioleic acid

(Rac)-Idroxioleic acid  (Synonyms: 2-Hydroxyoleic acid; 2-OHOA)

目录号: HY-129467 纯度: ≥98.0%
COA 产品使用指南

(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) 是一种合成油酸 (OA) 衍生物,能与质膜结合改变脂质组织。(Rac)-Idroxioleic acid 具有抗肿瘤作用。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

(Rac)-Idroxioleic acid Chemical Structure

(Rac)-Idroxioleic acid Chemical Structure

CAS No. : 56472-29-8

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥2134
In-stock
1 mg ¥650
In-stock
5 mg ¥1300
In-stock
10 mg ¥2100
In-stock
25 mg ¥4300
In-stock
50 mg ¥6900
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect[1].

体外研究
(In Vitro)

(Rac)-Idroxioleic acid (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM[1].
(Rac)-Idroxioleic acid (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Jurkat cells
Concentration: 25 μM, 50 μM, 75 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Impaired Jurkat cell growth in a time- and concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: Jurkat cells
Concentration: 25 μM, 50 μM
Incubation Time: 72 hours
Result: Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP.
体内研究
(In Vivo)

(Rac)-Idroxioleic acid markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old nude male mice (Jurkat cells xenograft model)[1]
Dosage: 600 mg/kg
Administration: Oral administration; daily; for 21 days
Result: Markedly and significantly inhibited tumour growth.
分子量

298.46

Formula

C18H34O3

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (335.05 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3505 mL 16.7527 mL 33.5053 mL
5 mM 0.6701 mL 3.3505 mL 6.7011 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

参考文献

(Rac)-Idroxioleic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3505 mL 16.7527 mL 33.5053 mL 83.7633 mL
5 mM 0.6701 mL 3.3505 mL 6.7011 mL 16.7527 mL
10 mM 0.3351 mL 1.6753 mL 3.3505 mL 8.3763 mL
15 mM 0.2234 mL 1.1168 mL 2.2337 mL 5.5842 mL
20 mM 0.1675 mL 0.8376 mL 1.6753 mL 4.1882 mL
25 mM 0.1340 mL 0.6701 mL 1.3402 mL 3.3505 mL
30 mM 0.1117 mL 0.5584 mL 1.1168 mL 2.7921 mL
40 mM 0.0838 mL 0.4188 mL 0.8376 mL 2.0941 mL
50 mM 0.0670 mL 0.3351 mL 0.6701 mL 1.6753 mL
60 mM 0.0558 mL 0.2792 mL 0.5584 mL 1.3961 mL
80 mM 0.0419 mL 0.2094 mL 0.4188 mL 1.0470 mL
100 mM 0.0335 mL 0.1675 mL 0.3351 mL 0.8376 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
(Rac)-Idroxioleic acid
目录号:
HY-129467
需求量: