2. Apoptosis Metabolic Enzyme/Protease
  3. Apoptosis Mitochondrial Metabolism
  4. MitoTam bromide, hydrobromide

MitoTam bromide, hydrobromide 他莫昔芬衍生物，它是一种电子传递链 (ETC) 抑制剂，抑制衰老细胞中的线粒体膜电位变化并影响线粒体形态。MitoTam bromide, hydrobromide 是一种有效的抗癌剂，可以抑制乳腺癌细胞中呼吸复合物 (CI-respiration) 和超复合物 (SCs) 的形成。

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MitoTam bromide, hydrobromide Chemical Structure

MitoTam bromide, hydrobromide Chemical Structure

CAS No. : 1634624-73-9

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MitoTam bromide, hydrobromide 的其他形式现货产品:

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Other Forms of MitoTam bromide, hydrobromide:

MitoTam bromide, hydrobromide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MitoTam bromide, hydrobromide, a Tamoxifen derivative[1], is an electron transport chain (ETC) inhibitor. MitoTam bromide, hydrobromide reduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology[2]. MitoTam bromide, hydrobromide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells[1][2].

体外研究
(In Vitro)

MitoTam (0.5 μM-56 μM；24 小时) 杀死乳腺癌细胞系和非恶性细胞，IC50 范围为 0.65 μM 至 55.9 μM[1]。
与模拟 MCF7 细胞[1] 相比，MitoTam (2.5 μM；2-24 小时) 导致 MCF7 Her2 高细胞凋亡途径的激活更强。
MitoTam (0.05 μM- 1 μM；3 天) 在乳腺癌细胞中引起浓度依赖性凋亡诱导，而对非恶性乳腺上皮细胞没有影响[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MitoTam bromide, hydrobromide 相关抗体:

Cell Viability Assay[1]

Cell Line: Breast Cancer Cell Lines: BT474, MCF7, MCF7 Her2high, MCF7 Her2low, MDA-MB-231, MDA-MB-436, MDA-MB-453, SK-BR-3, T47D; NeuTL cells; Nonmalignant Cells: A014578, H9c2 cells
Concentration: 0.5 μM-56 μM
Incubation Time: 24 hours
Result: Killed breast cancer cells MCF7, MCF7 Her2high, MCF7 Her2low with IC50 values of 1.25 μM, 0.65 μM and 1.45 μM respectively.

Western Blot Analysis[1]

Cell Line: MCF7 mock cells, MCF7 Her2high cells
Concentration: 2.5 μM
Incubation Time: 2 hours, 4 hours, 8 hours, 16 hours, 24 hours
Result: Revealed accelerated cleavage of procaspase-9, Parp1/2 and proapoptotic Bax, decreased the antiapoptotic Bcl-2 protein in Her2high cells.

Apoptosis Analysis[2]

Cell Line: MCF-7 cells, 4T1 cells and MCF-10a cells
Concentration: 0.05 μM-1 μM
Incubation Time: 3 days
Result: Resulted in apoptosis in MCF7 and 4T1 cells.
体内研究
(In Vivo)

MitoTam (腹膜内注射；2 μg/g；每周一次；4 周) 减少 MitoTam 处理小鼠肺部的 β-gal 染色，同时与对照小鼠相比，还抑制衰老标记物 p16Ink4a、p21waf1 和 PAI 的表达[2]。
MitoTam (腹膜内注射；0.54 μMol/小鼠；每周两次；2 周) 抑制同系肿瘤生长 80%[1]。
MitoTam (腹膜内注射；0.25 μMol/小鼠；每周两次；2 周) 减缓 MCF7 模拟肿瘤的生长并在两次给药后停止肿瘤进展；抑制 Her2high 癌从原始大小缩小三倍并完全消失[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 18-month-old or 2-month-old FVB/N mice[2]
Dosage: 2 μg/g
Administration: Intraperitoneal injection; 2 μg/g; once a week; 4 weeks
Result: Eliminated senescent cells also in vivo.
Animal Model: FVB/N c-neu mouse[1]
Dosage: 0.54 μmol/mouse
Administration: Intraperitoneal injection; 0.54 μmol/mouse; twice a week; 2 weeks
Result: Suppressed Her2high breast carcinomas.
Animal Model: Balb/c nude mice with MCF7 mock or MCF7 Her2high cells[1]
Dosage: 0.25 μmol/mouse/dose
Administration: Intraperitoneal injection; 0.25 μmol/mouse/dose; twice a week; 2 weeks
Result: Prevented reaching the ethical endpoint in all situations, slowed down the growth of MCF7 mock tumors and suppressed Her2high carcinomas decreased.
分子量

905.82

Formula

C52H60Br2NOP
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 240 mg/mL (264.95 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1040 mL 5.5199 mL 11.0397 mL
5 mM 0.2208 mL 1.1040 mL 2.2079 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

MitoTam bromide, hydrobromide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1040 mL 5.5199 mL 11.0397 mL 27.5993 mL
5 mM 0.2208 mL 1.1040 mL 2.2079 mL 5.5199 mL
10 mM 0.1104 mL 0.5520 mL 1.1040 mL 2.7599 mL
15 mM 0.0736 mL 0.3680 mL 0.7360 mL 1.8400 mL
20 mM 0.0552 mL 0.2760 mL 0.5520 mL 1.3800 mL
25 mM 0.0442 mL 0.2208 mL 0.4416 mL 1.1040 mL
30 mM 0.0368 mL 0.1840 mL 0.3680 mL 0.9200 mL
40 mM 0.0276 mL 0.1380 mL 0.2760 mL 0.6900 mL
50 mM 0.0221 mL 0.1104 mL 0.2208 mL 0.5520 mL
60 mM 0.0184 mL 0.0920 mL 0.1840 mL 0.4600 mL
80 mM 0.0138 mL 0.0690 mL 0.1380 mL 0.3450 mL
100 mM 0.0110 mL 0.0552 mL 0.1104 mL 0.2760 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MitoTam bromide,1634624-73-9ApoptosisMitochondrial MetabolismTamoxifenelectrontransportchainETCmitochondrialmembranebreastcancerInhibitorinhibitorinhibit

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