2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Muscarinic M4 modulator-1

Muscarinic M4 modulator-1 是一种 Muscarinic M4 receptor 正向变构调节剂。Muscarinic M4 modulator-1 可激活毒蕈碱 M4 受体，对 CHO-K1 细胞和 HEK293 细胞的变构效力 EC50 分别为 14 nM 和 3 nM。Muscarinic M4 modulator-1 具有抗精神病样活性，具有精神和/或神经系统疾病的研究潜力。

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Muscarinic M4 modulator-1 Chemical Structure

Muscarinic M4 modulator-1 Chemical Structure

CAS No. : 3082186-91-9

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Muscarinic M4 modulator-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Muscarinic M4 modulator-1 is a Muscarinic M4 receptor positive allosteric modulator. Muscarinic M4 modulator-1 activates the muscarinic M4 receptor with allosteric potency EC50 s of 14 and 3 Nm in CHO-K1 cells and HEK293 cells. Muscarinic M4 modulator-1 has an antipsychotic-like activity, promising for psychiatric and/or neurological disorders research[1].

IC50 & Target

mAChR4

 

体外研究
(In Vitro)

Muscarinic M4 modulator-1 (Example 4) ( 0.2-4 小时) 对 CHO-K1 细胞和 HEK293 细胞中的毒蕈碱 M4 受体的变构效力 EC50 分别为 14 nM 和 3 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Muscarinic M4 modulator-1 相关抗体:
体内研究
(In Vivo)

Muscarinic M4 modulator-1 (Example 4) (10-30 mg/kg，腹腔注射，一次) 在大鼠模型中，剂量为 10 和 30 mg/kg 时受体占据率分别为 33.9% 和 66.7%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[1].
Dosage: 10, 30 mg/kg
Administration: i.p., once following administering intravenously with MK-6884 (3 μg/Kg) through lateral tail vein at Tmax.
Result: Caused 33.9% and 66.7% receptor occupancy at 10 and 30 mg/kg in rats.
分子量

412.44

Formula

C21H22F2N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Muscarinic M4 modulator-1 相关分类

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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Muscarinic M4 modulator-13082186-91-9mAChRMuscarinic acetylcholine receptorPositive allosteric modulatorMuscarinic M4 receptorAntipsychoticCHO-K1 cellsHEK293 cellsInhibitorinhibitorinhibit

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产品名称：
Muscarinic M4 modulator-1
目录号：
HY-174259
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