2. Metabolic Enzyme/Protease
  3. MMP
  4. ND-336

ND-336 是基质金属蛋白酶 (MMP)-2、MMP-9 和 MMP-14 的选择性抑制剂，Ki 分别为 85、150 和 120 nM。ND-336 通过降低炎症反应、促进创面血管生成和再上皮化，促进小鼠糖尿病创面愈合。

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ND-336 Chemical Structure

ND-336 Chemical Structure

CAS No. : 1807453-83-3

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规格 价格 是否有货
500 μg ￥1170
询问价格 & 货期
1 mg ￥1980
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Customer Review

Other Forms of ND-336:

ND-336 相关抗体

Top Publications Citing Use of Products

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14, with Kis of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound[1][2].

IC50 & Target[1]

MMP-2

85 nM (Ki)

MMP-9

150 nM (Ki)

MMP-14

120 nM (Ki)

体内研究
(In Vivo)

ND-336 accelerates diabetic wound healing by decreasing inflammation and by enhancing angiogenesis and re-epithelialization of the wound, thus reversing the pathological condition[1].
ND-336 (0.05-0.01 mg; topical application; daily for 14 day) accelerates diabetic wound healing[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female diabetic db/db mice[1]
Dosage: 0.05, 0.025, and 0.01 mg
Administration: Topical application; daily for 14 day
Result: Healed 1.2- to 1.6-fold faster than those treated with ND-322 than those treated with vehicle.
分子量

371.90

Formula

C16H18ClNO3S2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥95.0%

COA (260 KB)

产品使用指南 (1538 KB)
参考文献

ND-336 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ND-3361807453-83-3ND336ND 336MMPMatrix metalloproteinaseswoundhealinginflammationangiogenesisselectivediabeticInhibitorinhibitorinhibit

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产品名称：
ND-336
目录号：
HY-124373
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