2. Metabolic Enzyme/Protease
  3. MMP
  4. (R)-ND-336

(R)-ND-336 是一种有效的选择性 MMP-9 抑制剂，Ki 为 19 nM。(R)-ND-336 抑制 MMP-2 (Ki=127 nM) 和 MMP-14 (Ki=119 nM)。(R)-ND-336 具有用于糖尿病足溃疡 (DFUs) 研究的潜力。

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(R)-ND-336 Chemical Structure

(R)-ND-336 Chemical Structure

CAS No. : 2252493-33-5

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Other Forms of (R)-ND-336:

(R)-ND-336 相关抗体

Top Publications Citing Use of Products

查看 MMP 亚型特异性产品:

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(R)-ND-336 is a potent and selective MMP-9 inhibitor with a Ki of 19 nM. (R)-ND-336 inhibits MMP-2 (Ki=127 nM) and MMP-14 (Ki=119 nM). (R)-ND-336 has the potential for diabetic foot ulcers (DFUs) research[1].

IC50 & Target[1]

MMP-9

19 nM (Ki)

MMP-2

127 nM (Ki)

MMP-14

119 nM (Ki)

体外研究
(In Vitro)

(R)-ND-336 poorly inhibits other MMPs (Ki>100 μM). (R)-ND-336 has a long residence time (the time the inhibitor is bound to MMP-9, calculated as 1/koff) of 300 min[1].
A favorable IC50value of 143 μM afforded a therapeutic index (IC50/Ki for MMP-9) ratio of 7530, indicating that (R)-ND-336 is not cytotoxic[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-ND-336 相关抗体:
体内研究
(In Vivo)

(R)-ND-336 (50 μg/wound/day for 14 days) accelerates wound healing faster[1].
(R)-ND-336 has an AUC of 1.3 μM•min after topical administration and 35 μM•min following intravenous dosing, for an AUCtop/AUCiv ratio of 3.7%, indicating minimal absorption after topical administration in db/db mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female db/db mice (BKS.Cg-Dock7m+/+Leprdb/J, 8-weeks old, ∼40 g body weight)[1]
Dosage: 50 μg
Administration: Wound; once a day for 14 days
Result: Accelerated wound healing faster and showed complete inhibition of MMP-9.
分子量

371.90

Formula

C16H18ClNO3S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(R)-ND-336 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-ND-3362252493-33-5MMPMatrix metalloproteinasesdiabeticfootulcersDFUswoundInhibitorinhibitorinhibit

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产品名称：
(R)-ND-336
目录号：
HY-124373A
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