2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Anti-infection Apoptosis
  3. Reactive Oxygen Species (ROS) Fungal Mitochondrial Metabolism Apoptosis Endogenous Metabolite
  4. Nerol

Nerol  (Synonyms: 橙花醇)

目录号: HY-N7063 纯度: 98.97%
COA 产品使用指南 技术支持

Nerol 是橙花油的一种成分, Nerol 通过增强 Ca2+ 和 ROS 来触发线粒体功能障碍并诱导凋亡。具有抗真菌活性。

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Nerol

Nerol Chemical Structure

CAS No. : 106-25-2

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规格 价格 是否有货 数量
100 mg ￥100
In-stock
500 mg ￥184
In-stock
1 g ￥260
In-stock
5 g ￥480
In-stock
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Customer Review

Other Forms of Nerol:

Nerol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca2+ and ROS. Antifungal activity[1][2].

IC50 & Target

Apoptosis; ROS; Antifungal[1][2]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
> 100 μM
Compound: Nerol
Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
[PMID: 25455494]
HEK293 IC50
> 100 μM
Compound: Nerol
Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
[PMID: 25455494]
HEK293 IC50
> 100 μM
Compound: Nerol
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
[PMID: 25455494]
HEK293 EC50
11.7 μM
Compound: Nerol
Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
[PMID: 25455494]
体外研究
(In Vitro)

橙花醇诱导腐生真菌 Aspergillus flavus[1] 中与 ROS 和 Ca2+ 超载相关的细胞凋亡。
橙花醇 (NEL) 对白色念珠菌 (一种致病性真菌) 的活性具有 4.4 μM 的最低抑制浓度 (MIC)，可通过细胞凋亡样机制引起显著的念珠菌活性[2]。
在 白色念珠菌[2] 中，橙花醇通过升高 Ca2+ 和 ROS 触发线粒体功能障碍和破坏。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nerol 相关抗体:
分子量

154.25

Formula

C10H18O
CAS 号
性状

液体（密度：0.876 g/cm3）

颜色

Colorless to light yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 98.97%

COA (278 KB) GC (177 KB)

产品使用指南 (1538 KB)
参考文献

Nerol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nerol106-25-2Reactive Oxygen Species (ROS)FungalMitochondrial MetabolismApoptosisEndogenous MetaboliteAntifungalCalciumROSNELmitochondrialdysfunctionInhibitorinhibitorinhibit

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