2. Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease Anti-infection
  3. Sirtuin Endogenous Metabolite HBV
  4. Nicotinamide Hydrochloride

Nicotinamide Hydrochloride  (Synonyms: Niacinamide Hydrochloride; Nicotinic acid amide Hydrochloride)

目录号: HY-B0150A
产品使用指南 技术支持

Nicotinamide Hydrochloride 是维生素 B3 或烟酸的一种形式。Nicotinamide Hydrochloride 可抑制 SIRT2 的活性，其 IC50 值为 2 μM。Nicotinamide Hydrochloride 也抑制 SIRT1。Nicotinamide Hydrochloride 增加细胞内 NAD+、ATP、ROS 水平。Nicotinamide Hydrochloride 抑制肿瘤生长并提高生存率。Nicotinamide Hydrochloride 还具有抗-HBV 活性。

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Nicotinamide Hydrochloride Chemical Structure

Nicotinamide Hydrochloride Chemical Structure

CAS No. : 25334-23-0

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Nicotinamide Hydrochloride 的其他形式现货产品:

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Nicotinamide Hydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 54 篇科研文献

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    Nicotinamide Hydrochloride purchased from MCE. Usage Cited in: Pharmacol Res. 2024 Dec 31:107573.  [Abstract]

    Nicotinamide (NAM) (10 μM) enhanced ISO (10 μM)-induced YAP acetylation in neonatal rat cardiomyocytes (NRCMs).

    Nicotinamide Hydrochloride purchased from MCE. Usage Cited in: Oncoimmunology. 2025 Dec;14(1):2460281.  [Abstract]

    Nicotinamide (NAM) (6 h) promotes CPT2 acetylation in SK-N-AS cells.

    Nicotinamide Hydrochloride purchased from MCE. Usage Cited in: Apoptosis. 2024 Dec 25.  [Abstract]

    Nicotinamide (NAM) (20 mM; pretreatment for 24 hours before LPS exposure in MLE-12 cells) increases GPX4 acetylation levels in MLE-12 cells.

    Nicotinamide Hydrochloride purchased from MCE. Usage Cited in: Cell Death Differ. 2023 Oct 12.  [Abstract]

    Nicotinamide (NAM) (10 mM, 4 h)​​ enhances RACK1 acetylation levels in OVCAR3 and SKOV3 cells in combination with Trichostatin A (TSA) (HY-15144) (0.2 μM, 4 h).

    Nicotinamide Hydrochloride purchased from MCE. Usage Cited in: Cell Death Discov. 2022 May 17;8(1):265.  [Abstract]

    Nicotinamide (NAM) (6-8 h) upregulates stathmin1 acetylation in 293T cells transfected with stathmin1-Flag plasmids.

    Nicotinamide Hydrochloride purchased from MCE. Usage Cited in: Nat Commun. 2021 Jul 9;12(1):4227.  [Abstract]

    Nicotinamide (80 μM; 4-8 h) markedly increases GLDC K514 acetylation in U251 and U87 cells.

    Nicotinamide Hydrochloride purchased from MCE. Usage Cited in: Hum Reprod. 2020 Mar 27;35(3):494-503.  [Abstract]

    Nicotinamide (NAM) (40 mM; 1 h) increases the global level of lysine 2-hydroxyisobutyrylation along the human sperm tail.

    Nicotinamide Hydrochloride purchased from MCE. Usage Cited in: Hum Reprod. 2019 Jul 8;34(7):1186-1194.  [Abstract]

    Nicotinamide (NAM) (20-40 mM; 1 h) increases global levels of Kac (lysine acetylation) and Kglu (lysine glutarylation) in human sperm.

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    Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Nicotinamide Hydrochloride is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide Hydrochloride also inhibits SIRT1. Nicotinamide Hydrochloride increases cellular NAD+, ATP, ROS levels. Nicotinamide Hydrochloride inhibits tumor growth and improves survival. Nicotinamide Hydrochloride also has anti-HBV activity[1][2][3][4].

    IC50 & Target[1][2]

    Human Endogenous Metabolite

     

    SIRT2

    2 μM (EC50)

    SIRT1

    50-180 μM (IC50)

    体外研究
    (In Vitro)

    Nicotinamide Hydrochloride (0-50 mM，24/48 小时) 以时间依赖性和剂量依赖性方式减少 A375 和 SK-MEL-28 细胞中的细胞数量[1]。
    Nicotinamide Hydrochloride (10-50 mM, 24 h ) 使 A375 细胞在 G1 期积累，在 S 期减少，在亚 G1 期 (细胞凋亡)增加[1]。
    Nicotinamide Hydrochloride (1-50 mM，6 小时) 增加 A375 和 SK-MEL-28 细胞中的 NAD+、ATP 和 ROS 水平[1]。
    Nicotinamide Hydrochloride (0.01-20 mM，1 小时) 在体外抑制纯化的 SIRT2 酶活性，EC50 为 2 μM[1]。
    Nicotinamide Hydrochloride (0-64 mM) 抑制 HBV 在 HepAD38 和 HepG2.2.15 细胞中的复制[3]。
    Nicotinamide Hydrochloride (10 mM，第 13 天) 通过抑制 CK1 和 ROCK 促进胰腺细胞从人胚胎干细胞 (hESC) 分化[4]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Nicotinamide Hydrochloride 相关抗体:

    Cell Viability Assay[1]

    Cell Line: A375, SK-MEL-28, mouse B16-F10 cell
    Concentration: 0, 1, 20, 50 mM
    Incubation Time: 24 h, 48 h
    Result: Reduced cell number in a dose-dependent manner with a strong inhibitory effect at 20mM and an almost complete effect at 50 mM.

    Cell Cycle Analysis[1]

    Cell Line: A375, SK-MEL-28
    Concentration: 10, 20, 50 mM
    Incubation Time: 24 h
    Result: Arrested A375 cells in G1 phase.
    体内研究
    (In Vivo)

    Nicotinamide Hydrochloride (腹腔注射，1500 和 1800 mg/Kg，每周 5 天) 抑制小鼠转移性黑色素瘤模型中的肿瘤生长[1]。
    Nicotinamide Hydrochloride (腹腔注射，1800 mg/Kg，每天一次，小鼠转移性黑色素瘤模型) 影响 IFN-γ (细胞介导的抗肿瘤免疫的关键介质)，增加 Eotaxin 和 IL-5 的血浆水平，降低 IL-3、IL-12、RANTES 和 IL-10 的血浆水平[1]。
    Nicotinamide Hydrochloride (静脉注射，0-200 mg/kg，5 天) 抑制 HBV 转基因小鼠体内的 HBV 复制[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL/6 mice (subcutaneous injected with B16-F10 cells)[1]
    Dosage: 1000, 1500, 1800 mg/Kg.
    Administration: Intraperitoneal injection, 5 days per week (followed by 2-day rest) or once a day.
    Result: Inhibited tumor growth at 1500 and 1800 mg/Kg, and had no effect on the body weight.
    Increased the frequency of IFN-γ producing cells and modulated the protein levels of cytokines and chemokines in the plasma of tumor-bearing mice.
    Animal Model: HBV-transgenic mice[3]
    Dosage: 0-200 mg/kg
    Administration: Vein injection, 5 days
    Result: Reduced serum HBV DNA.
    Clinical Trial
    分子量

    158.59

    同用名

    Niacinamide Hydrochloride; Nicotinic acid amide Hydrochloride

    Formula

    C6H7ClN2O
    CAS 号
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Nicotinamide Hydrochloride 相关分类

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    • 稀释计算器

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Nicotinamide25334-23-0NiacinamideNicotinic acid amideSirtuinEndogenous MetaboliteHBVHepatitis B virusMelanomatumorA375 cellSK-MEL-28 cellskin cancerhESCsInhibitorinhibitorinhibit

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