2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NLRP3-IN-20

NLRP3-IN-20 (compound 11) 是一种口服有效的 NLRP3 炎症小体的抑制剂，抑制 IL-1β 分泌的 IC50 为 25 nM。NLRP3-IN-20 具有优秀的药代动力学特性，在非酒精性脂肪性肝炎、致命性感染性休克和结肠炎模型中有显著功效。

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NLRP3-IN-20 Chemical Structure

NLRP3-IN-20 Chemical Structure

CAS No. : 2428478-22-0

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NLRP3-IN-20 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis[1].

IC50 & Target

NLRP3[1]
体内研究
(In Vivo)


在小鼠中的药代动力学分析[1]

Route Dose (mg/kg) T1/2 (h) Tmax (h) Cmax (ng/mL) AUC0-inf (ng·h/mL) MRT0-inf (h) Vz (mL/kg) Cl (mL/h/kg) F (%)
i.v. 5 4.01 0.083 22567 130240/ 5.30 226 38.8
p.o. 10 3.50 0.667 33867 221955 4.79 / / 85.21

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

413.53

Formula

C22H27N3O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NLRP3-IN-20 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-202428478-22-0NOD-like Receptor (NLR)Inhibitorinhibitorinhibit

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目录号：
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