2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. O-7460

O-7460 是一种有效和选择性的 DAGLα 抑制剂，IC50 值为 0.69 μM。O-7460 对单酰基甘油脂肪酶 (MAGL) 以及人 CB1 和 CB2 大麻素受体具有选择性。O-7460 可以降低 HFD 引起的 2-AG 水平上调。

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O-7460 Chemical Structure

O-7460 Chemical Structure

CAS No. : 1572051-31-0

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规格 价格 是否有货 数量
500 μg ￥1706
3 - 4 周

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O-7460 相关抗体

Top Publications Citing Use of Products

查看 Cannabinoid Receptor 亚型特异性产品:

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CB1 CB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

O-7460 is a potent and selective DAGLα inhibitor, with an IC50 of 0.69 μM. O-7460 shows selectivity over onoacylglycerol lipase (MAGL), human CB1 and CB2 cannabinoid receptors. O-7460 can decrease HFD-caused an up-regulation of 2-AG levels[1].

IC50 & Target

IC50: 0.69 μM (DAGLα)[1]
体外研究
(In Vitro)

O-7460 (10 μM; 20 min) decreases the Ionomycin (3 μM)-induced formation of 2-AG in N18TG2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

O-7460 相关抗体:
体内研究
(In Vivo)

O-7460 (6-12 mg/kg; a single i.p.) induces a time- and dose-dependent decrease in high-fat diet (HFD) intake and counteracts the body weight increase of mice[1].
O-7460 (12 mg/kg; i.p.) decreases the HFD-caused an up-regulation of 2-AG levels in the hypothalamus and liver of mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Seven-week-old male C57BL/6N inbred mice were administrated high-fat diet (HFD) diet[1]
Dosage: 6, 12 mg/kg
Administration: A single i.p.
Result: Induced a time (30 min, 60 min and 14 h after O-7460 administration) and dose-dependent decrease in HFD intake.
The highest dose significantly counteracted the body weight increase.
分子量

478.62

Formula

C25H48FO5P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

O-7460 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

O-74601572051-31-0O7460O 7460Cannabinoid ReceptorDAGLα2-AGobesityInhibitorinhibitorinhibit

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