2. Protein Tyrosine Kinase/RTK Immunology/Inflammation
  3. FGFR Interleukin Related
  4. Oncaspar

Oncaspar  (Synonyms: PEG-L-asparaginase; Pegasparaginase)

目录号: HY-108860 纯度: ≥99.0%
COA 技术支持

Oncaspar (PEG-L-asparaginase; Pegasparaginase) 是来自 Escherichia coli 的 L-天冬酰胺酶的聚乙二醇化形式，可分解血液中循环的氨基酸天冬酰胺。Oncaspar 通过天冬酰胺水解和激活综合应激反应 (ISR) 通路在急性淋巴细胞白血病 (ALL) 中发挥重要作用。

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Oncaspar

Oncaspar Chemical Structure

CAS No. : 130167-69-0

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规格 价格 是否有货 数量
5 mL ￥13500
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Oncaspar 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Oncaspar (PEG-L-asparaginase; Pegasparaginase), a pegylated form of native Escherichia coli-derived L-asparaginase, breaks down the amino acid asparagine that are circulating in the bloodstream. Oncaspar plays an important role in acute lymphoblastic leukemia (ALL) through asparagine hydrolysis and activation of the integrated stress response (ISR) pathway[1].

体外研究
(In Vitro)

Oncaspar (2 IU/mL, 48 h) 抑制 266-6 细胞活力，抑制 ATF3/4 蛋白表达，并促进 FGF21 蛋白表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Oncaspar 相关抗体:

Cell Viability Assay[2]

Cell Line: 266-6
Concentration: 2 IU/mL
Incubation Time: 48 h
Result: Inhibited the cell viability.

Western Blot Analysis[2]

Cell Line: 266-6
Concentration: 2 IU/mL
Incubation Time: 48 h
Result: Downregulated the expression of ATF3 proteins, upregulated the expression of FGF21 protein.
体内研究
(In Vivo)

Oncaspar (1 IU/g, intramuscular, single dose) 引起大鼠胰腺水肿和炎症浸润，在 Sprague-Dawley 大鼠模型中诱发炎症反应[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats models[2]
Dosage: 1 IU/g
Administration: intramuscular, single dose
Result: Increased plasma lipase levels, inhibited the weight gain of rats, increased the levels of inflammatory markers IL6 and IL1β in pancreatic tissue, caused edema and inflammatory infiltration in the pancreases of rats.
Clinical Trial
应用

ELISA, FACS, Functional assay
偶联物

Conjugated with pegol
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
CAS 号
性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥99.0%

COA (274 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Oncaspar 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oncaspar130167-69-0PEG-L-asparaginase PegasparaginaseFGFRInterleukin RelatedFibroblast growth factor receptorILlymphoblastic leukemia (ALL)L-asparaginasePEGInhibitorinhibitorinhibit

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目录号：
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