2. Immunology/Inflammation
  3. Interleukin Related
  4. Ordesekimab

Ordesekimab  (Synonyms: AMG 714; PRV-015)

目录号: HY-P99410 纯度: 95.00%
COA

摩尔计算器

Ordesekimab (AMG 714; PRV-015) 是一种人 IgG1κ 抗 IL-15 (Interleukin Related) 单克隆抗体。Ordesekimab 与 IL-15 的结合抑制 IL-15 与 IL-2Rβ 和 IL-15 受体复合物的共同 γ 链的相互作用，但不与 IL-15Rα 链相互作用。Ordesekimab 具有研究无反应性乳糜泻 (NRCD) 的潜力。

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Ordesekimab Chemical Structure

Ordesekimab Chemical Structure

CAS No. : 879293-15-9

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规格 价格 是否有货 数量
1 mg ￥1200
In-stock
5 mg ￥2500
In-stock
10 mg ￥4100
In-stock
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Ordesekimab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ordesekimab (AMG 714; PRV-015) is a fully human IgG1κ anti-IL-15 (Interleukin Related) monoclonal antibody. The binding of Ordesekimab to IL-15 inhibits the interaction of IL-15 with the IL-2Rβ and common γ chain of the IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab has the potential for study of nonresponsive celiac disease (NRCD)[1].

IC50 & Target[1]

IL-15

 

体外研究
(In Vitro)

The simultaneous binding of Ordesekimab (AMG 714) to the Fcγ receptor (R) IIIα expressed on natural killer (NK) cells and to the IL-15/IL-15Rα complex on cells such as monocytes may theoretically enable antibody-dependent cell-mediated cytotoxicity (ADCC) toward the IL-15Rα-expressing cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ordesekimab 相关抗体:
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

奥司奇单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ordesekimab 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ordesekimab879293-15-9AMG 714 PRV-015奥司奇单抗AMG714AMG-714PRV015PRV 015PRV-015Interleukin RelatedILnonresponsive celiac diseaseIL-15IgG1κIL-2RβInhibitorinhibitorinhibit

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