2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. PARP Apoptosis
  4. OUL312

OUL312 是一种强效的 PARP10 抑制剂 (IC50 = 20 nM)，对 PARP15 的选择性比 PARP10 高 75 倍上(IC50 = 1500 nM)。OUL312 的活性也至少比该家族中所有其他人类酶高 18 倍。OUL312 具有良好的 ADME 特性，能够进入细胞，无毒性，并且在亚微摩尔浓度下即可有效阻止 PARP10 诱导的人类细胞凋亡 (apoptosis)。OUL312 可用于宫颈癌的研究。

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OUL312

OUL312 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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3.  试用装只面向终端客户。

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OUL312 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OUL312 is a potent PARP10 inhibitor (IC50 = 20 nM), showing more than 75-fold greater selectivity for PARP15(IC50 = 1500 nM). OUL312 is also at least 18-fold higher than all other human enzymes in the family. OUL312 has a good ADME profile, is able to enter cells, is not toxic, and effectively rescues human cells from PARP10-induced apoptosis at sub-micromolar concentrations. OUL312 can be used for the study of cervical cancer[1].

IC50 & Target

PARP10

 

体外研究
(In Vitro)

OUL312 (Compound 15) (0.05-10 μM，10-12 天) 在 HeLa Flp-In TRex 细胞中未显示出明显的细胞毒性，并且能够以浓度依赖的方式挽救Doxycycline (HY-N0565) 诱导的 HeLa Flp-In TRex 细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

OUL312 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HeLa Flp-In T-Rex cells
Concentration: 10 μM
Incubation Time: 10-12 days
Result: Showed no significant cytotoxicity.

Cell Proliferation Assay[1]

Cell Line: Doxycycline-induced HeLa Flp-In T-Rex cells
Concentration: 0.05 μM, 0.1 μM, 0.5 μM, 1 μM, 10 μM
Incubation Time: 10-12 days
Result: Rescued cells in a concentration-dependent manner with apparent EC50 below 1 μM.
分子量

300.28

Formula

C16H13FN2O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

OUL312 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OUL312OUL 312OUL-312PARPApoptosispoly ADP ribose polymerase 2,3-Dihydrophthalazine-1,4-dioneADP-RibosylationInhibitorPARP10inhibitorinhibit

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目录号：
HY-178317
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