2. Immunology/Inflammation
  3. CD3
  4. Pacanalotamab

Pacanalotamab  (Synonyms: AMG 420; BI-836909)

目录号: HY-P99798 纯度: 97.04%
COA

摩尔计算器

Pacanalotamab (AMG 420；BI-836909) 是一种双特异性 T 细胞接合剂 (BiTE)，靶向 BCMA 和 CD3ɛ。BCMA 是指 B 细胞成熟抗原，而 Pacanalotamab 会将 T 细胞重定向到细胞表面的 BCMA 表达细胞。Pacanalotamab 可对人多发性骨髓瘤 (MM) 细胞系进行 T 细胞重定向裂解。

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Pacanalotamab Chemical Structure

Pacanalotamab Chemical Structure

CAS No. : 2251756-52-0

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1 mg ￥6000
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Pacanalotamab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pacanalotamab (AMG 420; BI-836909) is a bispecific T-cell engager (BiTE) targeting to BCMA and CD3ɛ. BCMA refers to B cell maturation antigen, as Pacanalotamab redirecting T cells to BCMA expressing cells on the cell surface. Pacanalotamab conducts T-cell redirected lysis of human multiple myeloma (MM) cell lines[1].

IC50 & Target

B cell maturation antigen, BCMA; CD3ɛ[1]
体外研究
(In Vitro)

Pacanalotamab (1 pg/mL-100 ng/mL；24 h) 通过 T 细胞激活诱导 BCMA 依赖性肿瘤细胞裂解[1]。Pacanalotamab 诱导人多发性骨髓瘤细胞系的剂量依赖性重定向裂解，EC90 值范围为 16-810 pg/mL[1]。
Pacanalotamab (100 ng/mL；24 小时) 诱导磷脂酰丝氨酸从质膜内层转移到外层，导致 MM.1R 细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pacanalotamab 相关抗体:
体内研究
(In Vivo)

Pacanalotamab (50 µg/kg/天；静脉内或皮下注射；持续 18 天) 在小鼠 NCI-H929 异种移植模型中表现出抗肿瘤活性[1]。
Pacanalotamab (5 µg/kg/天；静脉注射或皮下注射) 在小鼠原位 L-363 异种移植模型中显着延长小鼠的存活时间[1]。
Pacanalotamab (静脉注射，135 µg/kg/天，或皮下注射，405 µg/kg/天；共 7 天) 耐受性良好，在毒性研究中它减少了猕猴骨髓中的浆细胞[1]< /sup>。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkey studies[1]
Dosage: (1) 0, 5, 15, 45 or 135 μg/kg/day, 20 mL/kg/day; (2) 135 or 405 μg/kg/day, 2 mL/kg/day
Administration: Intravenous injection for (1) and subcutaneous injection for (2); for 7 days
Result: Showed well tolerated among Cynomolgus monkeys. Clinical signs of toxicity were limited to vomiting and increased body temperature at 4-8 h.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pacanalotamab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pacanalotamab2251756-52-0AMG 420 BI-836909AMG420AMG-420BI836909BI 836909BI-836909CD3Cluster of differentiation 3Inhibitorinhibitorinhibit

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