2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt Immunology/Inflammation
  3. JAK Interleukin Related STAT
  4. Patiromer

Patiromer 是一种口服有效、选择性和非吸收性的肠道钾离子 (K+) 聚合物结合剂，以钙离子 (Ca2+) 交换的方式可逆性结合钾离子。Patiromer 可快速且持续降低血清钾水平，维持正常血钾状态，同时可降低血清醛固酮水平。Patiromer 还增加粪便钾排泄。Patiromer 主要用于慢性肾脏病、糖尿病、心力衰竭等疾病相关高钾血症的研究，尤其适用于改善肾素-血管紧张素-醛固酮系统抑制剂 (RAASi) 疗法。

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Patiromer Chemical Structure

Patiromer Chemical Structure

CAS No. : 1208912-84-8

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Patiromer 相关抗体

Top Publications Citing Use of Products

查看 JAK 亚型特异性产品:

查看所有亚型
JAK1 JAK2 JAK3 Tyk2 JAK

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Patiromer is an orally active, selective and non-absorbable intestinal potassium (K+) polymer binder that reversibly binds potassium ions in exchange for calcium (Ca2+). Patiromer can rapidly and continuously reduce serum potassium levels, maintain a normal blood potassium state, and reduce serum aldosterone levels. Patiromer also increases fecal potassium excretion. Patiromer is mainly used in the study of hyperkalemia associated with diseases such as chronic kidney disease, diabetes, and heart failure, and is particularly suitable for improving renin-angiotensin-aldosterone system inhibitor (RAASi) therapy[1][2][3].

IC50 & Target

JAK3

33.1 nM (IC50)

IL-2

 

IL-4

 

IL7R

 

IL-15

 

STAT3

 

STAT5

 

STAT6

 

体外研究
(In Vitro)

Patiromer 是一种无钠、不吸收的 K+ 结合聚合物[2]。
Patiromer 在体外的钾结合能力显著高于聚苯乙烯磺酸盐等传统树脂，具有高容量钾结合特性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Patiromer 相关抗体:
体内研究
(In Vivo)

Patiromer (4 g/kg；口服灌胃；每天 1 次；8 天或 12 周) 在单侧肾切除并诱导慢性高钾血症的雄性自发性高血压大鼠模型中，可显著降低血清 K+ 和醛固酮水平[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Spontaneously hypertensive rats (SHR) (male, 200-250 g, 7-9 weeks old) with unilateral nephrectomy (UniNx)[2]
Dosage: 4 g/kg
Administration: Oral gavage, once daily, 8 days; rats were induced chronic hyperkalemia by 3% potassium diet and amiloride.
Result: Significantly reduced serum K+ from baseline at days 4 and 8, and serum aldosterone was reduced to baseline levels, with no significant clinical distress in animals.
Clinical Trial
Formula

C28H48CaFO2+
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at 4°C, do not freeze
溶解性数据
细胞实验： 

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥95.0%

COA (264 KB)

产品使用指南 (1538 KB)
参考文献

Patiromer 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Patiromer1208912-84-8JAKInterleukin RelatedSTATJanus kinaseILelectrolyte disorderdialysisheart failurehyperkalemiahypertensionpatiromerpotassiumkidney diseaseInhibitorinhibitorinhibit

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