2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Pegaptanib sodium

Pegaptanib sodium  (Synonyms: EYE001; NX1838)

目录号: HY-109561 纯度: 98.09%
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Pegaptanib sodium 是一种靶向血管内皮生长因子 (VEGF)-165 的 RNA适配体。 Pegaptanib 可用于新生血管型老年性黄斑变性的研究。

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Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ester with RNA ((2′-deoxy-2′-fluoro)C-Gm-Gm-A-A-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-Am-Gm-(2′-deoxy-2′-fluoro)U-Gm-Am-Am-(2′-deoxy-2′-fluoro)U-Gm-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-Am-(2′-deoxy-2′-fluoro)U-Am-(2′-deoxy-2′-fluoro)C-Am-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)C-Gm-(3′→3′)-dT) 5′-[5-[[2,6-bis(carboxyamino)-1-oxohexyl]amino]pentyl hydrogen phosphate] (2:1), sodium salt

Pegaptanib sodium Chemical Structure

CAS No. : 222716-86-1

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规格 价格 是否有货 数量
1 mg ￥1940
In-stock
5 mg ￥4840
In-stock
10 mg 现货 询价
50 mg   询价  
100 mg   询价  

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Customer Review

Pegaptanib sodium 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pegaptanib sodium is an RNA aptamer directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) [1].

体外研究
(In Vitro)

Pegaptanib sodium 还能抑制 VEGF165 介导的 VEGFR2 和磷脂酶 Cγ 磷酸化，并抑制 VEGF165 诱导的人脐静脉内皮细胞钙动员[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pegaptanib sodium 相关抗体:
Clinical Trial
分子量

50000 (Approximately)

CAS 号
性状

固体

颜色

White to off-white

Sequence

RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2?-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'?3')-dT), 5'-ester with ?,?'-[4,12-dioxo-6-[[[5-(phosphoonoxy)pentyl]amino]carbonyl]-3,13-dioxa-5,11-diaza-1,15-pentadecanediyl]bis[?-methoxypoly(oxy-1,2-ethanediyl)], sodium salt
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 10 mg/mL (超声助溶)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Pegaptanib sodium 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pegaptanib222716-86-1EYE001 NX1838EYE 001EYE-001NX1838NX 1838NX-1838VEGFRVascular endothelial growth factor receptorocularneovasculardiseaseVEGFanti-angiogenicInhibitorinhibitorinhibit

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