1. 诱导疾病模型产品 Membrane Transporter/Ion Channel
  2. 神经系统疾病模型 Potassium Channel
  3. 震颤模型
  4. Penitrem A

Penitrem A  (Synonyms: 青霉震颤素A)

目录号: HY-N6776 纯度: 98.44%
COA 产品使用指南

Penitrem A 是由青霉菌产生的吲哚二萜神经毒性生物碱,是一种选择性的 BK 通道拮抗剂,对多种恶性肿瘤具有抗增殖、抗侵袭作用。Penitrem A 能刺激脑皮质突触体增加内源性谷氨酸、GABA 和天门冬氨酸的自发释放,能诱发动物产生震颤综合征。

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Penitrem A Chemical Structure

Penitrem A Chemical Structure

CAS No. : 12627-35-9

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1 mg ¥2240
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5 mg ¥5600
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals[1][2].

IC50 & Target

BK channel[1]

体内研究
(In Vivo)

Penitrem A 可用于动物建模,构建震颤综合征模型。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

634.20

Formula

C37H44ClNO6

CAS 号
性状

固体

颜色

White to light brown

中文名称

青霉震颤素A

结构分类
初始来源

Penicillium

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

参考文献
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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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目录号:
HY-N6776
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