2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Petosemtamab

Petosemtamab  (Synonyms: MCLA 158)

目录号: HY-P99406 纯度: 95.00%
COA

摩尔计算器

Petosemtamab (MCLA 158) 是一种抗 EGFR (Kd: 0.22 nM) 和抗 LGR5 (Kd: 0.86 nM) 单克隆抗体 (mAb)。Petosemtamab 导致 LGR5+ 癌细胞中的 EGFR 信号传导阻断和受体降解。Petosemtamab 可用于头颈部鳞状细胞癌 (HNSCC)、转移性结直肠癌 (CRC) 等实体瘤的研究。

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Petosemtamab Chemical Structure

Petosemtamab Chemical Structure

CAS No. : 2213450-26-9

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规格 价格 是否有货 数量
1 mg ￥3600
In-stock
5 mg ￥8500
In-stock
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50 mg   询价  

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Customer Review

Petosemtamab 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Petosemtamab (MCLA 158) is an anti- EGFR (Kd: 0.22 nM) and anti-LGR5 (Kd: 0.86 nM) monoclonal antibody (mAb). Petosemtamab leads to EGFR signaling blockade and receptor degradation in LGR5+ cancer cells. Petosemtamab can be used in the research of solid tumors, such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC)[1][2].

IC50 & Target[2]

EGFR

0.22 nM (Kd)

LGR5

0.85 nM (Kd)

体外研究
(In Vitro)

MCLA-158 (1 µg/mL，24 或 72 小时) 导致 EGFR+/LGR5+ 结直肠癌类器官中的 EGFR 降解[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Petosemtamab 相关抗体:

Western Blot Analysis[2]

Cell Line: P18T (KRAS WT), C55T (KRAS G12V) and C82N (normal) organoids
Concentration: 1 µg/mL
Incubation Time: 1, 6, 24, 72 h
Result: Time-dependently degraded EGFR.
体内研究
(In Vivo)

MCLA-158 (25 mg/kg/周，静脉注射，持续 6 周) 导致食管鳞癌、胃腺癌和头颈部 PDX 模型的肿瘤消退[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Esophageal squamous, gastric adenocarcinoma and head & neck PDX models[2]
Dosage: 25 mg/kg/week
Administration: Intravenous injection (i.v.) for 6 weeks.
Result: Inhibited tumor growth.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Petosemtamab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Petosemtamab2213450-26-9MCLA 158MCLA158MCLA-158EGFREpidermal growth factor receptorErbB-1HER1CRCcolorectal cancerHNSCChead and neck squamous cell carcinomaEGFR degradationInhibitorinhibitorinhibit

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目录号：
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