1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. PF-03654746 Tosylate

PF-03654746 Tosylate 

目录号: HY-11044
产品使用指南

PF-03654746 Tosylate (PF-03654746) 是一种有效的选择性组胺 H3 receptor 拮抗剂,具有脑渗透性。PF-03654746 Tosylate (PF-03654746) 可减少过敏原引起的鼻炎反应。PF-03654746 Tosylate (PF-03654746) 用于治疗人类认知障碍,改善阿尔茨海默病人 (AD) 的认知。

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PF-03654746 Tosylate Chemical Structure

PF-03654746 Tosylate Chemical Structure

CAS No. : 1039399-17-1

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1 mg ¥1500 In-stock
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Description

PF-03654746 Tosylate is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 Tosylate reduces allergen-induced nasal symptoms[1]. PF-03654746 Tosylate has potential for treatment of human cognitive disorders, improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD)[2].

IC50 & Target

H3 receptor[1]

Molecular Weight

494.59

Formula

C₂₅H₃₂F₂N₂O₄S

CAS No.

1039399-17-1

SMILES

O=C([C@H]1C[C@](C1)(F)C2=CC=C(CN3CCCC3)C(F)=C2)NCC.O=S(C4=CC=C(C)C=C4)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
PF-03654746 Tosylate
目录号:
HY-11044
需求量:

PF-03654746 Tosylate

Cat. No.: HY-11044