2. Membrane Transporter/Ion Channel
    Neuronal Signaling
  3. nAChR
  4. PHA 568487

PHA 568487 

目录号: HY-107666
产品使用指南

PHA 568487 是 α-7 烟碱乙酰胆碱受体 (α-7 nAchR) 的选择性激动剂。PHA 568487 可减少神经炎症和氧化应激。PHA-568487 可快速透过血脑屏障。

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PHA 568487 Chemical Structure

PHA 568487 Chemical Structure

CAS No. : 527680-57-5

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规格 价格 是否有货
5 mg ￥4500
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生物活性

PHA 568487 a selective agonist of alpha-7 nicotinic acetylcholine receptor (α-7 nAchR)[1][2].PHA 568487 reduces neuroinflammation and oxidative stress[2]. PHA-568487 has rapid brain penetration[3].

体外研究
(In Vitro)

PHA 568487 increases anti-oxidant gene expression and decreases oxidative stress and phosphorylation of NF-κb p65. Methyllycaconitine (MLA) has the opposite effects[2].
PHA increases anti-oxidant genes and NADPH oxidase expression associated with decreased phosphorylation of NF-kB p65 in microglia/macrophages[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

PHA 568487 attenuates neuronal injury and behavioral dysfunction in mice with ischemic stroke only and ischemic stroke plus tibia fracture[2].
PHA 568487 (1.25 mg/kg; i.p.; treated daily)-treated ischemic rats shows a significant reduction of the cerebral infarct volumes and an improvement of the neurologic outcome[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J male mice (10-12 weeks old)[2]
Dosage: PHA 568487 (PHA; 0.4 and 0.8 mg/kg); Methyllycaconitine (MLA; 4 and 6 mg/kg)
Administration: Injected intraperitoneally once on day 1, or twice on days 1 and 2, after pMCAO
Result: Injection of PHA (0.8 mg/kg) and MLA (6 mg/kg) on days 1 and 2 after pMCAO yielded the best effect on infarct volume and behavior tests.
Animal Model: Adult male Sprague-Dawley rats (297 6±8.3 g)[4]
Dosage: 1.25 mg/kg
Administration: I.p.;0.1 mL; treated daily
Result: Showed a significant reduction of the cerebral infarct volumes and an improvement of the neurologic outcome.
分子量

404.41

Formula

C20H24N2O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

Keywords:

PHA 568487527680-57-5PHA568487PHA-568487nAChRNicotinic acetylcholine receptorsMacrophagepolarizationmiddlecerebralarteryocclusionneuroinflammationBraininjuryischemicstroketibiafractureBloodbrainbarrierintegrityOxidativestressInhibitorinhibitorinhibit

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