2. PI3K/Akt/mTOR Anti-infection
  3. PI3K SARS-CoV
  4. PI3Kδ-IN-27

PI3Kδ-IN-27 是一种 PI3Kδ 抑制剂，其 IC50 为 355.3 nM。PI3Kδ-IN-27 具有抗 SARS-CoV-2 活性。PI3Kδ-IN-27 可用于感染相关研究，如新冠肺炎。

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PI3Kδ-IN-27

PI3Kδ-IN-27 Chemical Structure

CAS No. : 3097471-25-2

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PI3Kδ-IN-27 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3Kδ-IN-27 is an PI3Kδ inhibitor with an IC50 of 355.3 nM. PI3Kδ-IN-27 exhibits anti-SARS-CoV-2 activity. PI3Kδ-IN-27 can be used for the research of infection, such as COVID-19[1].

IC50 & Target[1]

PI3Kδ

355.3 nM (IC50)

SARS-CoV-2

 

体外研究
(In Vitro)

PI3Kδ-IN-27 在 Vero E6 细胞中对 SARS-CoV-2 Beta、Delta、Omicron 毒株均有抑制作用，IC50 值分别为 5.60 μM、5.43 μM、4.97 μM，选择性指数 (SI) 分别为 24.89、25.66、28.04[1]。
PI3Kδ-IN-27 对 Vero-E6 和 A549 细胞的 CC50 值分别为 139.36 μM、125.79 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3Kδ-IN-27 相关抗体:
体内研究
(In Vivo)

PI3Kδ-IN-27 (15 mg/kg，腹腔注射，每日一次，持续 4 天) 在感染 SARS-CoV-2 的金黄仓鼠模型中，可显著抑制肺组织病毒复制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Golden hamsters infected with SARS-CoV-2[1]
Dosage: 15 mg/kg
Administration: Intraperitoneally injection, daily for 4 days
Result: Reduced the lung viral load to 14.1% of that in the placebo group Alleviated weight loss of hamsters, and decreased the viral titer in nasal turbinates.
分子量

380.44

Formula

C21H24N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3Kδ-IN-27 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kδ-IN-273097471-25-2PI3KSARS-CoVPhosphoinositide 3-kinaseSARS coronavirusSARS-CoV-2PI3KδinfectionVero-E6A549golden hamstersCOVID-19Inhibitorinhibitorinhibit

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目录号：
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