2. JAK/STAT Signaling Apoptosis
  3. Pim Apoptosis Caspase
  4. Pim-1 kinase-IN-14

Pim-1 kinase-IN-14 是一种 PIM-1 激酶抑制剂，其 IC50 值为 94 nM。Pim-1 kinase-IN-14 对多种人类癌细胞系表现出广谱且高效的抗癌活性，包括肝癌 (HepG-2)、结肠癌 (Caco-2)、髓系白血病 (NFS-60) 和前列腺癌 (PC-3) 细胞。Pim-1 kinase-IN-14 通过诱导凋亡 (apoptosis) 和激活 caspase 3/7 发挥其抗癌作用。Pim-1 kinase-IN-14 可用于研究与 PIM-1 激酶过表达相关的癌症。

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Pim-1 kinase-IN-14

Pim-1 kinase-IN-14 Chemical Structure

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Pim-1 kinase-IN-14 相关抗体

Top Publications Citing Use of Products

查看 Pim 亚型特异性产品:

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PIM1 PIM2 PIM3

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pim-1 kinase-IN-14 is a PIM-1 kinase inhibitor with an IC50 value of 94 nM. Pim-1 kinase-IN-14 shows broad-spectrum and high-efficiency anticancer activity against multiple human cancer cell lines, including liver cancer (HepG-2), colon cancer (Caco-2), myeloid leukemia (NFS-60), and prostate cancer (PC-3) cells. Pim-1 kinase-IN-14exerts its anticancer effects by inducing apoptosis and activating caspase 3/7. Pim-1 kinase-IN-14 can be used for the study of cancers associated with PIM-1 kinase overexpression[1].

IC50 & Target[1]

PIM1

 

体外研究
(In Vitro)

Pim-1 kinase-IN-14 (Compound 6e) 对 HepG-2、Caco-2、NFS-60 和 PC-3 细胞表现出强效的抗癌活性[1]。
Pim-1 kinase-IN-14 在 HepG-2、Caco-2、PC-3 和 NFS-60 细胞中诱导凋亡[1]。
Pim-1 kinase-IN-14 在 HepG-2 细胞中显著激活 caspase 3/7[1]。
Pim-1 kinase-IN-14 对 PIM-1 激酶显示出强效的抑制活性，其 IC50 值为 0.094 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pim-1 kinase-IN-14 相关抗体:
分子量

661.07

Formula

C34H25ClN8O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pim-1 kinase-IN-14 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pim-1 kinase-IN-14PimApoptosisCaspasePim kinasesCancersPim-1 kinaseHepG-2Caco-2NFS-60PC-3caspase 3/7apoptosisInhibitorinhibitorinhibit

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