2. JAK/STAT Signaling
  3. Pim
  4. Pim-1 kinase inhibitor 9

Pim-1 kinase inhibitor 9（compound 8b）是一种针对 Pim-1 kinase 的选择性抑制剂，IC50 值是 0.24 µM。Pim-1 kinase inhibitor 9 将乳腺细胞 T47D 细胞的细胞周期阻滞在 S 期。Pim-1 kinase inhibitor 9 具有抗肿瘤活性。

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Pim-1 kinase inhibitor 9 Chemical Structure

Pim-1 kinase inhibitor 9 Chemical Structure

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Pim-1 kinase inhibitor 9 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pim-1 kinase inhibitor 9 (compound 8b) is a selective inhibitor against Pim-1 kinase with IC50 value of 0.24 µM. Pim-1 kinase inhibitor 9 inhibits cell cycle of T47D at S phase. Pim-1 kinase inhibitor 9 reveals antitumor activity[1].

IC50 & Target

PIM1

0.24 μM (IC50)

PIM2

10.53 μM (IC50)

体外研究
(In Vitro)

Pim-1 kinase inhibitor 9 抑制乳腺癌细胞 T47D 的生长，IC50值为9.8 μM（48h）和 2.61 μM（96h）[1]。
Pim-1 kinase inhibitor 9 抑制 Pim-1 kinase 和 Pim-2 kinase 的活性，IC50 值为 0.24 μM（Pim-1 kinase）和 10.53 μM（Pim-2 kinase）[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pim-1 kinase inhibitor 9 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: T47D
Concentration: 10 μM
Incubation Time: 48 h and 96 h
Result: Exhibited cytotoxicity activity to T47D with IC50 value of 9.8 μM (48 h) and 2.61μM (96h).

Cell Cycle Analysis[1]

Cell Line: T47D
Concentration: 10 μM
Incubation Time: 48 h
Result: Inhibited cell cycle at S phase.
体内研究
(In Vivo)

Pim-1 kinase inhibitors 9（1 mg/kg，每周一次，共三周，腹腔注射）通过促进 caspase-3 的表达和抑制 VEGF 的表达来抑制小鼠Ehrlich实体瘤的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: swiss albino mice/Ehrlich solid carcinoma model[1]
Dosage: 1 mg/kg
Administration: i.p. injected once a week, for 3 weeks
Result: Inhibited growth of Ehrlich solid tumours in mice.
分子量

614.73

Formula

C36H24F2N4S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pim-1 kinase inhibitor 9 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pim-1 kinase inhibitor 9PimPim kinasesPim-1 kinaseantitumorbreast cancerT47Dcaspase-3VEGFInhibitorinhibitorinhibit

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