2. Others Neuronal Signaling GPCR/G Protein
  3. Adrenergic Receptor Isotope-Labeled Compounds
  4. Prazobind-d8

Prazobind-d8 (SZL 49-d8) 是 Prazobind (HY-118335) 的氘代物。Prazobind 是一种哌唑嗪类似物，是一种 α1-肾上腺素能受体 (α1-adrenoceptor) 拮抗剂。Prazobind 竞争 α1-肾上腺素能受体结合位点，在富含 α1A (海马) 和 α1B (肝脏) 亚型的组织中，其效果相似 (IC50 为 1 nM)。Prazobind 可部分抑制环形肌、纵形肌和脾脏平滑肌收缩。Prazobind 可用于血压研究。

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Prazobind-d8

Prazobind-d8 Chemical Structure

CAS No. : 1189701-23-2

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Prazobind-d8 相关抗体

Top Publications Citing Use of Products

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

生物活性

Prazobind-d8 (SZL 49-d8) is the deuterium labeled Prazobind (HY-118335). Prazobind, a prazosin analog, is an irreversible α1-adrenoceptor antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC50 of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind partially inhibits the contractions of circular muscles, longitudinal muscles and smooth muscles of the spleen. Prazobind can be used for the study of blood pressure.

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Prazobind-d8 相关抗体:
分子量

429.54

Formula

C23H19D8N5O3
CAS 号
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Prazobind-d8 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Prazobind-d81189701-23-2SZL 49-d8Adrenergic ReceptorIsotope-Labeled CompoundsBeta ReceptorInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-118335S
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