2. Others Metabolic Enzyme/Protease Neuronal Signaling Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Reference Standards Cytochrome P450 Monoamine Oxidase Bcl-2 Family Survivin PARP
  4. Proadifen hydrochloride (Standard)

Proadifen hydrochloride (Standard)  (Synonyms: SKF-525A (Standard); U-5446 (Standard); RP-5171 (Standard))

目录号: HY-B1311R 纯度: ≥98%
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Proadifen (hydrochloride) (Standard)是 Proadifen (hydrochloride) 的分析标准品。本产品用于研究及分析应用。Proadifen (SKF-525A) hydrochloride 是一种非竞争性 Cytochrome P450 抑制剂，其 IC50 值为 19 μM。Proadifen hydrochloride 降低大鼠单胺氧化酶 A (MAO-A) 活性，并逆转 Imipramine (HY-B1490A) 和 Desipramine (HY-B1272A) 抗抑郁样行为。Proadifen hydrochloride 也降低肝微粒体 N, N-dimethyltryptamine (DMT) 代谢，抑制 N-demethylation 和 Acridone (HY-W007771) 的形成。Proadifen hydrochloride 在大鼠中增加 Lipopolysaccharide (LPS) (HY-D1056) 诱导的发烧并加剧 Prostaglandin E2 (PGE2) (HY-101952) 水平。Proadifen hydrochloride 有望用于代谢相关疾病，卵巢癌，炎症和多巴胺神经元相关疾病的研究。

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Proadifen hydrochloride (Standard) Chemical Structure

Proadifen hydrochloride (Standard) Chemical Structure

CAS No. : 62-68-0

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生物活性

Proadifen (hydrochloride) (Standard) is the analytical standard of Proadifen (hydrochloride). This product is intended for research and analytical applications. Proadifen (SKF-525A) hydrochloride is a non-competitive Cytochrome P450 inhibitor with an IC50 value of 19 μM. Proadifen hydrochloride reduces monoamine oxidase A (MAO-A) activity and reverses the antidepressantlike behavioral effect of Imipramine (HY-B1490A) and Desipramine (HY-B1272A) in rats. Proadifen hydrochloride also reduces N, N-dimethyltryptamine (DMT) metabolism in liver microsomes and inhibits N-demethylationand Acridone (HY-W007771) formation. Proadifen hydrochloride augments Lipopolysaccharide (LPS) (HY-D1056)-induced fever and exacerbates Prostaglandin E2 (PGE2) (HY-101952) levels in the rat. Proadifen hydrochloride is promising for research of metabolism-related deseases, ovarian carcinoma, inflammation and dopamine neurons-related deseases[4].

分子量

389.96

同用名

SKF-525A (Standard); U-5446 (Standard); RP-5171 (Standard)

Formula

C23H32ClNO2
CAS 号
中文名称

盐酸普罗地芬 (Standard)；普罗地芬盐酸盐 (Standard)
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Proadifen hydrochloride (Standard) 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Proadifen hydrochloride (Standard)62-68-0SKF-525A (Standard)U-5446 (Standard)RP-5171 (Standard)盐酸普罗地芬 (Standard)普罗地芬盐酸盐 (Standard)Reference StandardsCytochrome P450Monoamine OxidaseBcl-2 FamilySurvivinPARPCYPsMAOpoly ADP ribose polymeraseCytochrome P450 inhibitormonoamine oxidase AantidepressantDMTliver microsomesAcridoneprostaglandin E2ratayahuascainflammationovarian carcinomaInhibitorinhibitorinhibit

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