2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. PTAC oxalate

PTAC oxalate 是一种选择性毒蕈碱受体 (muscarinic receptor) 配体。PTAC oxalate 是 M2 和 M4 的部分激动剂，是 M1、M3 和 M5 的拮抗剂，对于 CHO 细胞中的 hM1-5，Ki 值为 0.2-2.8 nM。PTAC oxalate 减轻神经性疼痛的机械异常性疼痛并具有抗抑郁作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PTAC oxalate Chemical Structure

PTAC oxalate Chemical Structure

CAS No. : 201939-40-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PTAC oxalate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PTAC oxalate is a selective muscarinic receptor ligand. PTAC oxalate is an partial agonist of M2 and M4 but antagonist of M1, M3, and M5 (Ki values of 0.2-2.8 nM for hM1-5 in CHO cells). PTAC oxalate alleviates the mechanical allodynia on the neuropathic pain and has antidepression effects[1][2].

IC50 & Target[1][2]

mAChR1

0.6 nM (Ki)

mAChR2

2.8 nM (Ki)

mAChR3

0.2 nM (Ki)

mAChR4

0.2 nM (Ki)

mAChR5

0.8 nM (Ki)

体内研究
(In Vivo)

PTAC oxalate (0.01, 0.05 mg/kg; 腹腔给药) 在 0.05 mg/kg 时可以减轻机械异常性疼痛。PTAC oxalate 在 0.05 mg/kg 剂量下可缩短假手术组和神经损伤组小鼠的不动时间，但在 0.01 mg/kg 剂量下则不会[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse model of neuropathic pain[2]
Dosage: 0.01, 0.05 mg/kg
Administration: IP
Result: The mechanical allodynia was alleviated with 0.05 mg/kg.
At 0.05 mg/kg increased the paw withdrawal thresholds (PWTs) of the nerve-injury groups injected at day 4 after nerve injury.
At 0.01 mg/kg had no effect on the PWTs in the sham and nerve-injury groups injected at day 14 after nerve injury.
分子量

359.46

Formula

C14H21N3O4S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PTAC oxalate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTAC201939-40-4mAChRMuscarinic acetylcholine receptorMuscarinicmechanicalallodynianeuropathic painantidepressionInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PTAC oxalate
目录号：
HY-107656
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z