1. Cell Cycle/DNA Damage
  2. Checkpoint Kinase (Chk)
  3. PV-1019

PV-1019  (Synonyms: NSC 744039)

目录号: HY-125203
产品使用指南

PV-1019 (NSC 744039) 是一种有效的选择性 Chk2 抑制剂,IC50 值为 24 nM。PV-1019 抑制 Topotecan (HY-13768) 诱导的 Chk2 自磷酸化。PV-1019 抑制 IR 诱导的细胞凋亡。

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PV-1019 Chemical Structure

PV-1019 Chemical Structure

CAS No. : 1093793-05-5

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查看 Checkpoint Kinase (Chk) 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PV-1019 (NSC 744039) is a potent, selective Chk2 inhibitor with an IC50 value of 24 nM. PV-1019 inhibits the Topotecan (HY-13768)-induced Chk2 autophosphorylation. PV-1019 inhibits IR-induced apoptosis[1].

IC50 & Target[1]

Chk2

24 nM (IC50)

体外研究
(In Vitro)

PV-1019 (NSC 744039; 0.1-100 μM; 48 h) 在人类肿瘤细胞中具有抗增殖作用[1]
PV-1019 抑制 Chk2 自磷酸化和组蛋白 H1 磷酸化,IC50 值为 138 nM[1]
PV-1019 (1-50 μM; 1 h; OVCAR-5 细胞) 抑制 Topotecan-诱导的 Chk2 自磷酸化,IC50 值为 2.8 μM[1]
PV-1019 (1 μM; 16 h) 消除小鼠胸腺细胞中 IR 诱导的细胞凋亡[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: human tumor cells
Concentration: 0.1-100 μM
Incubation Time: 48 hours
Result: Inhibited cell growth in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: OVCAR-5 cells
Concentration: 1, 5, 10, and 25 μM
Incubation Time: 1 hours
Result: Decreased the level of Chk2 autophosphorylation (Ser516) in a dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: mouse thymocytes
Concentration: 1 μM
Incubation Time: 16 hours
Result: Decreased in the sub-G1 fraction (56%).
分子量

379.37

Formula

C18H17N7O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PV-1019
目录号:
HY-125203
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