2. Metabolic Enzyme/Protease Anti-infection Membrane Transporter/Ion Channel Apoptosis
  3. Cytochrome P450 Parasite Potassium Channel Apoptosis
  4. Quinidine sulfate dihydrate

Quinidine sulfate dihydrate  (Synonyms: 硫酸奎尼宁)

目录号: HY-B1751D
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摩尔计算器

Quinidine sulfate dihydrate 是一种抗心律失常剂。Quinidine sulfate dihydrate 是一种有效的、具有口服活性的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，也是 K+ 通道 (K+ channel) 的有效阻断剂，其 IC50 值为 19.9 μM，也可诱导凋亡。Quinidine sulfate dihydrate 也可用作疟疾的研究。

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Quinidine sulfate dihydrate Chemical Structure

Quinidine sulfate dihydrate Chemical Structure

CAS No. : 6591-63-5

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Other Forms of Quinidine sulfate dihydrate:

Quinidine sulfate dihydrate 相关抗体

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查看 Cytochrome P450 亚型特异性产品:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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  • 参考文献

生物活性

Quinidine sulfate dihydrate is an antiarrhythmic agent. Quinidine sulfate dihydrate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate dihydrate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine sulfate dihydrate can be used for malaria research[1][2][3][4].

IC50 & Target

IC50: cytochrome P450db; amphetamine metabolism[1]
体外研究
(In Vitro)

Quinidine sulfate dihydrate shows cytotoxicity against MES-SA cells, and induces apoptosis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Quinidine sulfate dihydrate 相关抗体:
体内研究
(In Vivo)

Quinidine sulfate dihydrate shows effects on the PTZ-induced seizure threshold[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5]
Dosage: 10, 20, and 30 mg/kg
Administration: Intraperitoneal injection; 10, 20, and 30 mg/kg; once
Result: Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).
分子量

405.50

Formula

C21H30N2O7S
CAS 号
中文名称

硫酸奎尼宁
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Quinidine sulfate dihydrate 相关分类

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinidine sulfate dihydrate6591-63-5硫酸奎尼宁Cytochrome P450ParasitePotassium ChannelApoptosisCYPsKcsAoral activitymalariaMES-SAMESSA/DX5Inhibitorinhibitorinhibit

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