1. MAPK/ERK Pathway
  2. Raf
  3. RAF mutant-IN-1

RAF mutant-IN-1 

目录号: HY-126298
产品使用指南

RAF mutant-IN-1 是RAF kinase 的抑制剂,信息来自专利WO2019107987A1,对C-RAF 340D/Y341D、B-RAFV600E 和B-RAFWTIC50 值分别为 21 nM、30 nM和392 nM。

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RAF mutant-IN-1 Chemical Structure

RAF mutant-IN-1 Chemical Structure

CAS No. : 2340020-82-6

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Description

RAF mutant-IN-1 is a RAF kinase inhibitor, extracted from patent WO2019107987A1, with IC50 values of 21 nM, 30 nM and 392 nM for C-RAF 340D/Y341D, B-RAFV600E and B-RAFWT, respectively[1].

IC50 & Target

C-RAF 340D/Y341D

21 nM (IC50)

B-RafV600E

30 nM (IC50)

BRAFWT

392 nM (IC50)

Molecular Weight

567.85

Formula

C₂₃H₁₈Cl₃FN₆O₂S

CAS No.

2340020-82-6

SMILES

O=C(C1=CSC2=C(N)N=CN=C21)NC3=C(C)C=CC4=C3C=CN=C4NC5=CC=C(O)C(Cl)=C5F.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
RAF mutant-IN-1
目录号:
HY-126298
需求量:

RAF mutant-IN-1

Cat. No.: HY-126298