Raf Inhibitors

Braf, IC₅₀: 22 nM
Braf^V599E, IC₅₀: 38 nM

Raf-1, IC₅₀: 6 nM

BRaf^V600E, IC₅₀: 0.6 nM

CRAF, IC₅₀: 5 nM

B-Raf^V600E, IC₅₀: 31 nM

c-Raf-1, IC₅₀: 48 nM

BRaf^V600E, IC₅₀: 19 nM
Braf, IC₅₀: 28 nM

Raf-1, IC₅₀: 2.5 nM

B-Raf, IC₅₀: 83.4 nM

BRaf^V600E, IC₅₀: 5 nM

B-Raf

Braf, IC₅₀: 22 nM
Braf^V599E, IC₅₀: 38 nM

Raf-1, IC₅₀: 6 nM

B-Raf, Ki: 0.16 nM

c-Raf, Ki: 1.72 nM

B-Raf^V600E, IC₅₀: 13 nM
B-Raf, IC₅₀: 160 nM

BRaf^V600E, IC₅₀: 8.2 nM
Braf, IC₅₀: 190 nM

CRAF, IC₅₀: 56 nM

BRaf^V600E, IC₅₀: 7 nM
B-Raf, IC₅₀: 56 nM

CRAF, IC₅₀: 5 nM

BRaf^V600E, IC₅₀: 5.8 nM
Braf, IC₅₀: 9.1 nM

CRAF, IC₅₀: 15 nM

B-Raf, IC₅₀: 0.13 nM

BRaf^V600E, IC₅₀: 0.6 nM

CRAF, IC₅₀: 5 nM

RAF

c-Raf, IC₅₀: 9 nM

B-Raf, IC₅₀: 105 nM
B-Raf^V600E, IC₅₀: 34 nM

c-Raf-1, IC₅₀: 29 nM

Braf, IC₅₀: 0.21 nM

CRAF, IC₅₀: 0.072 nM

RAF

BRaf^V600E, IC₅₀: 23 nM

Braf, Kd: 36 nM
BRaf^V600E, Kd: 14 nM

CRAF, Kd: 39 nM

Braf, IC₅₀: 8.3 nM

c-Raf, IC₅₀: 1.4 nM

BRaf^V600E, IC₅₀: 19 nM
Braf, IC₅₀: 28 nM

Raf-1, IC₅₀: 2.5 nM

BRaf^V600E, IC₅₀: 19 nM
Braf, IC₅₀: 28 nM

Raf-1, IC₅₀: 2.5 nM

RAF

RAF

BRaf^V600E, IC₅₀: 0.04 μM
Braf, IC₅₀: 0.1 μM

CRAF, IC₅₀: 0.01 μM

BRaf^V600E, IC₅₀: 5 nM (in mutant RAS expressing cells)

Braf, IC₅₀: 0.6 nM
BRaf^V600E, IC₅₀: 0.4 nM

c-Raf, IC₅₀: 0.8 nM

c-Raf, IC₅₀: 0.07 μM (0.1 mM ATP)

Braf, IC₅₀: 0.4 nM

CRAF, IC₅₀: 0.5 nM

RAF

B-Raf, Kd: 2.4 nM

B-Raf^V600E, IC₅₀: 76 nM
BRAF^WT, IC₅₀: 238 nM

RAF

B-Raf, Ki: 1 nM
B-Raf^V600E, Ki: 1 nM

c-Raf, Ki: 0.3 nM

B-Raf^V600E, IC₅₀: 0.09 μM (in Ba/F3 cells)

B-Raf

BRaf^V600E, IC₅₀: 4.25 nM

B-Raf

Braf, Ki: 0.19 nM

CRAF, Ki: 0.062 nM

RAF

BRAF-V600E, Kd: 2 nM
Braf, Kd: 2.4 nM

B-Raf, IC₅₀: 24 nM

BRaf^V600E, IC₅₀: 38 nM
BRAF^WT, IC₅₀: 79 nM

CRAF, IC₅₀: 68 nM

BRaf^V600E

BRaf^V600E

Braf, IC₅₀: 50-100 nM
BRAF-V600E, IC₅₀: < 50 nM

B-Raf, IC₅₀: 11.7 nM

B-Raf

c-Raf

Braf

B-Raf, IC₅₀: 28 ± 10 nM
BRaf^V600E, IC₅₀: 19 ± 6 nM

Raf-1, IC₅₀: 2.5 ± 0.6 nM

c-Raf

B-Raf^V600E, IC₅₀: 30 nM
BRAF^WT, IC₅₀: 392 nM

C-RAF ^340D/Y341D, IC₅₀: 21 nM

Braf, IC₅₀: 7.0 nM

BRaf^V600E, IC₅₀: 3.55 nM

RAF, IC₅₀: 2.1 nM

Braf, IC₅₀: 30 nM
BRaf^V600E, IC₅₀: 15 nM

CRAF, IC₅₀: 6 nM

B-Raf, IC₅₀: 70.65 ± 0. nM

BRaf^V600E, IC₅₀: 29.4 nM
BRAF^WT, IC₅₀: 36 nM

c-Raf, IC₅₀: 3.8 nM

BRaf^V600E, IC₅₀: 0.063 μM
BRAF^WT, IC₅₀: 0.005 μM

BRAF-V600E, Kd: 9.5 nM
Braf, Kd: 14.4 nM

BRaf^V600E, IC₅₀: 0.089 μM
BRAF^WT, IC₅₀: 0.071 μM

BRaf^V600E, IC₅₀: 5.7 nM
BRAF^WT, IC₅₀: 10 nM

c-Raf, IC₅₀: 1.6 nM

BRaf^V600E, IC₅₀: 45 nM

Braf

CRAF

Braf

B-Raf, IC₅₀: 24.97 ± 0. nM

B-Raf, IC₅₀: 110.23 ± 0 nM

BRaf^V600E, Kd: 14 nM
Braf, Kd: 36 nM

CRAF, Kd: 39 nM

B-Raf, Ki: 1 nM
B-Raf^V600E, Ki: 1 nM

c-Raf, Ki: 0.3 nM