Rapamycin  (Synonyms: 雷帕霉素 (GMP); Sirolimus; AY-22989)

Rapamycin (Sirolimus) (GMP) is Rapamycin (HY-10219) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Rapamycin is a potent and specific mTOR inhibitor^[1][2][3].

Rapamycin (GMP)（1 nM；2-3 周）可诱导人胚胎干细胞 (hESC) 体外分化为矿化成骨细胞^[1]。
Rapamycin (GMP)（1 nM；2-3 周）可增强人胚状体 (hEB) 的成骨细胞分化^[1]。
Rapamycin (GMP)（20 nM；4 小时）血清依赖性促进血管平滑肌细胞 (VSMC) 分化^[2]。
Rapamycin (GMP) 诱导大鼠成骨细胞样骨肉瘤细胞的成骨细胞分化^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

914.17

C₅₁H₇₉NO₁₃

53123-88-9

雷帕霉素 (GMP)； 西罗莫司 (GMP)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lee KW, et al. Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway. Stem Cells Dev. 2010 Apr;19(4):557-68.  [Content Brief]

  [2]. Martin KA, et al. Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling. J Biol Chem. 2007 Dec 7;282(49):36112-20.  [Content Brief]

  [3]. Ogawa T, et al. Osteoblastic differentiation is enhanced by rapamycin in rat osteoblast-like osteosarcoma (ROS 17/2.8) cells. Biochem Biophys Res Commun. 1998 Aug 10;249(1):226-30.  [Content Brief]