2. 重组蛋白
  3. Receptor Proteins
  4. ASGR1/ASGPR1 蛋白, Human (HEK293, hFc)

ASGR1/ASGPR1 蛋白, Human (HEK293, hFc)

目录号: HY-P704413
产品使用指南 技术支持

ASGR1/ASGPR1 介导去唾液酸化糖蛋白的内吞作用，识别半乳糖和 N-乙酰半乳糖胺单位。配体结合导致内化和分选细胞器运输，然后受体返回细胞膜。ASGR1/ASGPR1 与 LASS2 相互作用。ASGR1/ASGPR1 蛋白, Human (HEK293, hFc) 是重组的 ASGR1/ASGPR1 蛋白，由 HEK293 表达，带有 N-hFc 标签。

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50 μg   询价  
100 μg   询价  

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描述

ASGR1/ASGPR1 mediates endocytosis of desialylated glycoproteins, recognizing galactose and N-acetylgalactosamine units. Ligand binding leads to internalization and sorting organelle transport, followed by receptor return to the cell membrane. ASGR1/ASGPR1 interacts with LASS2. ASGR1/ASGPR1 Protein, Human (HEK293, hFc) is the recombinant human-derived ASGR1/ASGPR1 protein, expressed by HEK293, with N-hFc labeled tag.
研究背景

ASGR1/ASGPR1 蛋白在血浆糖蛋白的内吞作用中充当介质，特别是那些复杂碳水化合物部分上的末端唾液酸残基已被去除的血浆糖蛋白。该受体表现出对末端半乳糖和 N-乙酰半乳糖胺单元的识别能力。配体与受体结合后，形成的复合物经历内化并被转运至分选细胞器，在该细胞器中受体和配体解离。随后，受体返回到细胞膜表面。ASGR1/ASGPR1 与 LASS2 相互作用。
种属

Human
表达系统

HEK293
标签

N-hFc
蛋白编号

P07306-1 (Q62-L291)
基因 ID

432
蛋白结构
N-term
hFc
ASGR1 (Q62-L291)
Accession # P07306
C-term
蛋白长度

Extracellular Domain
同用名
rHuASGR1, His; Asialoglycoprotein Receptor 1, ASGR1,
预测分子量
52.8 kDa
分子量

Approximately 65-75 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
糖基化修饰
Yes
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

ASGR1/ASGPR1 Protein, Human (HEK293, hFc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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