1. 重组蛋白
  2. Cytokines and Growth Factors CAR-T related Proteins CD Antigens
  3. TNF Superfamily B Cell CD Proteins
  4. TNF Receptor Superfamily BCMA/CD269
  5. B Cell Maturation Antigen (BCMA)
  6. BCMA/TNFRSF17 蛋白, Rat (HEK293, Fc)

BCMA/TNFRSF17 蛋白, Rat (HEK293, Fc)

目录号: HY-P75591
产品使用指南

B Cell Maturation Antigen (BCMA) 也称为 TNFRSF17 或 CD269,是肿瘤坏死因子受体 (TNFR) 超家族的跨膜糖蛋白成员。BCMA 用作多发性骨髓瘤 (MM) 的生物标志物。BCMA 主要在 B 细胞增殖、存活以及分化为浆细胞方面发挥重要作用。BCMA/TNFRSF17 蛋白, Rat (HEK293, Fc) 是一种由 HEK293 细胞表达重组蛋白,其 C 末端带有 Fc 标签,由 49 (M1-T49) 个氨基酸组成。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

  • 参考文献

描述

B Cell Maturation Antigen (BCMA) also referred to as TNFRSF17 or CD269, is a transmembrane glycoprotein member of the tumor necrosis factor receptor (TNFR) superfamily. BCMA is used as a biomarker for Multiple myeloma (MM). BCMA mainly plays an important role in B cells for their proliferation, survival and also differentiates them into plasma cells[1]. BCMA/TNFRSF17 Protein, Rat (HEK293, Fc) is a recombinant protein with a C-Terminal Fc label, It consists of 49 amino acids (M1-T49) and is produced in HEK293 cells.

研究背景

BCMA 优先由成熟 B 淋巴细胞表达,在造血干细胞或非造血组织中表达最少[1]。BCMA 几乎只在浆母细胞和 PC 上表达[2]
人 BCMA 蛋白的氨基酸序列与小鼠 BCMA 蛋白同源性较低。
BCMA 是一个 184 个氨基酸20.2-kDa III 型跨膜糖蛋白,其胞外 N 末端含有 6 个半胱氨酸的保守基序。BCMA 有两种激动剂配体:增殖诱导配体 (APRIL) 和 B 细胞激活因子 (BAFF)。配体与 BCMA 结合后,激活 B 细胞 (NF-κβ)、大鼠肉瘤/丝裂原激活蛋白激酶 (RAS/MAPK) 和磷酸肌醇 3 激酶蛋白激酶 B/Akt (PI3K-PKB/Akt)信号通路。这些途径通过调节细胞周期检查点来刺激增殖,通过上调抗凋亡蛋白来提高存活率,并产生细胞粘附分子、血管生成因子和免疫抑制分子[2]
BCMA可作为一种有前途的抗原,针对 MM 患者使用多种免疫疗法(包括 CART 细胞)进行靶向治疗[3]。BCMA 显着降低小鼠血浆 IgA、IgG 和 IgM 水平以及脾脏 Ig 重链 mRNA 水平[4]。在 BCMA−/− 小鼠中,PC 的长期存活受到损害,但缺乏 BCMA 对短寿命的 PC、B 细胞发育或早期体液免疫反应没有影响,并且脾结构和生发中心在这些 BCMA 缺陷小鼠[5]。BCMA 过表达可显着促进小鼠模型中异种移植 MM 细胞的体内生长[6]

种属

Rat

表达系统

HEK293

标签

N-hFc

蛋白编号

D3ZKQ8 (M1-T49)

基因 ID

287034  [NCBI]

蛋白结构
N-term
hFc
BCMA (M1-T49)
Accession # D3ZKQ8
C-term
中文名
重组大鼠 BCMA/TNFRSF17 蛋白 (HEK293, Fc)
同用名
Tumor necrosis factor receptor superfamily member 17; CD269; TNFRSF17; BCM; BCMA
分子量

Approximately 40 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
参考文献
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
BCMA/TNFRSF17 Protein, Rat (HEK293, Fc)
目录号:
HY-P75591
需求量: