Calcitonin/CALCA 蛋白, Human (HEK293, Fc)

Calcitonin, encoded by the CALCA gene, causes a rapid and transient decrease in blood calcium and phosphate levels by promoting the incorporation of these ions into bone. This physiological response highlights the role of calcitonin in regulating mineral homeostasis and underlines its impact on skeletal dynamics. Calcitonin/CALCA Protein, Human (HEK293, Fc) is the recombinant human-derived Calcitonin/CALCA protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Calcitonin/CALCA Protein, Human (HEK293, Fc) is 116 a.a., with molecular weight of 40-48 kDa.

降钙素由 CALCA 基因编码，通过促进这些离子与骨骼的结合，导致血钙和磷酸盐水平快速而短暂地降低。这种激素在钙稳态中发挥着至关重要的作用，作为一种反调节机制来维持血液中平衡的矿物质水平。此外，卡他钙素（一种源自 CALCA 基因的肽）被认为是一种有效的血浆钙降低因子。降钙素调节骨吸收和调节循环矿物质浓度的能力强调了其在骨骼健康和全身矿物质平衡中的重要性。进一步探索参与这些作用的分子途径可能有助于更深入地了解降钙素在与钙代谢异常相关的疾病中的作用和潜在的治疗应用。

Human

HEK293

C-hFc

P01258 (A26-N141)

796  [NCBI]

40-48 kDa

• 
  Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.