1. 重组蛋白
  2. Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens
  3. TNF Superfamily Stimulatory Immune Checkpoint Molecules T Cell CD Proteins B Cell CD Proteins Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins
  4. TNF Receptor Superfamily CD40 GITR/CD357
  5. CD40 蛋白, Canine (P.pastoris, His)

CD40 蛋白, Canine (P.pastoris, His)

目录号: HY-P75410
产品使用指南

CD40 蛋白是 TNFSF5/CD40LG 的受体,通过 TRAF6 和 MAP3K8 转导信号,激活巨噬细胞和 B 细胞中的 ERK,导致免疫球蛋白分泌。CD40 以单体和同二聚体形式存在,与 TRAF 蛋白(TRAF1、TRAF2、TRAF3、TRAF5 和 TRAF6)相互作用,其中与 TRAF6 和 MAP3K8 的相互作用对于 ERK 激活至关重要。CD40 蛋白, Canine (P.pastoris, His) 是重组的 CD40 蛋白,由 P. pastoris 表达,带有 C-His 标签。CD40 蛋白, Canine (P.pastoris, His) 全长 174 个氨基酸,分子量约为 ~20.4 kDa。

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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描述

CD40 Protein, the receptor for TNFSF5/CD40LG, transduces signals via TRAF6 and MAP3K8, activating ERK in macrophages and B cells, leading to immunoglobulin secretion. Existing as a monomer and homodimer, CD40 interacts with TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6), with its interaction with TRAF6 and MAP3K8 crucial for ERK activation. CD40 Protein, Canine (P.pastoris, His) is the recombinant canine-derived CD40 protein, expressed by P. pastoris , with C-His labeled tag. The total length of CD40 Protein, Canine (P.pastoris, His) is 174 a.a., with molecular weight of ~20.4 kDa.

研究背景

CD40 蛋白作为 TNFSF5/CD40LG 的受体,转导 TRAF6 和 MAP3K8 介导的信号,激活巨噬细胞和 B 细胞中的 ERK,最终诱导免疫球蛋白分泌。CD40 蛋白以单体和同二聚体形式存在,与各种 TRAF 蛋白相互作用,包括 TRAF1、TRAF2、TRAF3、TRAF5 和 TRAF6。此外,它与 TRAF6 和 MAP3K8 的相互作用对于 ERK 的激活至关重要。

种属

Canine

表达系统

P. pastoris

标签

C-His

蛋白编号

Q7YRL5 (E21-A194)

基因 ID

403469  [NCBI]

蛋白结构
N-term
CD40 (E21-A194)
Accession # Q7YRL5
His
C-term
同用名
Tumor Necrosis Factor Receptor Superfamily member 5; Bp50; CD40L Receptor; CDw40; TNFRSF5
分子量

Approximately 20.4 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD40 Protein, Canine (P.pastoris, His)
目录号:
HY-P75410
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