CD40 蛋白, Mouse (174a.a, HEK293, His)

CD40 protein is a TNFSF5/CD40LG receptor that transduces signals through the TRAF6 and MAP3K8 pathways, activates ERK in macrophages and B cells, and induces immunoglobulin secretion. CD40 exists in monomeric and homodimeric forms, interacts with TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6) and crucially mediates cellular responses to external signals. CD40 Protein, Mouse (174a.a, HEK293, His) is the recombinant mouse-derived CD40 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD40 Protein, Mouse (174a.a, HEK293, His) is 174 a.a., with molecular weight of 21-25 kDa.

CD40 蛋白作为 TNFSF5/CD40LG 的受体，通过 TRAF6 和 MAP3K8 途径转导信号，激活巨噬细胞和 B 细胞中的 ERK，从而诱导免疫球蛋白分泌。CD40 蛋白以单体和同二聚体形式存在，与 TRAF1、TRAF2、TRAF3、TRAF5 和 TRAF6 相互作用，在介导细胞对外部信号的反应中发挥着至关重要的作用。与 TRAF6 和 MAP3K8 的相互作用对于 ERK 的激活和随后的细胞过程尤其重要。

Mouse

HEK293

C-6*His

P27512 (L20-R193)

21939  [NCBI]

LGQCVTCSDKQYLHDGQCCDLCQPGSRLTSHCTALEKTQCHPCDSGEFSAQWNREIRCHQHRHCEPNQGLRVKKEGTAESDTVCTCKEGQHCTSKDCEACAQHTPCIPGFGVMEMATETTDTVCHPCPVGFFSNQSSLFEKCYPWTSCEDKNLEVLQKGTSQTNVICGLKSRMR

21-25 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.