1. 重组蛋白
  2. CD Antigens Complement System
  3. NK Cell CD Proteins Stem Cell CD Proteins Erythrocyte CD Proteins Complement Regulatory Proteins
  4. CD59
  5. CD59 蛋白, Human (Biotinylated, HEK293, His-Avi)

CD59 蛋白, Human (Biotinylated, HEK293, His-Avi)

目录号: HY-P78906
产品使用指南 技术支持

CD59 蛋白是补体膜攻击复合物 (MAC) 的有效抑制剂,可与组装的 C8 和/或 C9 补体结合,防止对渗透性孔形成至关重要的多个 C9 拷贝的掺入。其物种特异性抑制作用延伸至 T 细胞激活,与蛋白酪氨酸激酶复合以进行信号转导。CD59 蛋白, Human (Biotinylated, HEK293, His-Avi) 是重组的 CD59 蛋白,由 HEK293 表达,带有 C-Avi, C-His 标签。CD59 蛋白, Human (Biotinylated, HEK293, His-Avi) 全长 77 个氨基酸,分子量为 15-20 kDa。

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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描述

The CD59 protein is a potent inhibitor of the complement membrane attack complex (MAC) and binds to assembled C8 and/or C9 complement, preventing the incorporation of multiple C9 copies that are critical for permeability pore formation. Its species-specific inhibitory effects extend to T cell activation, complexing with protein tyrosine kinases for signal transduction. CD59 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD59 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CD59 Protein, Human (Biotinylated, HEK293, His-Avi) is 77 a.a., with molecular weight of 15-20 kDa.

研究背景

CD59 蛋白是补体膜攻击复合物 (MAC) 作用的有效抑制剂。它通过与组装 MAC 的 C8 和/或 C9 补体结合来发挥作用,从而阻止渗透孔形成所需的 C9 多个拷贝的掺入。值得注意的是,该抑制剂表现出物种特异性。此外,CD59 与蛋白酪氨酸激酶复合参与信号转导的 T 细胞激活。值得注意的是,虽然尿液中的可溶性 CD59 保留了其特异性补体结合活性,但其抑制 MAC 在细胞膜上组装的能力显着降低。

种属

Human

表达系统

HEK293

标签

C-Avi;C-His

蛋白编号

P13987 (L26-N102)

基因 ID

966  [NCBI]

中文名
生物素化 CD59 蛋白
同用名
CD59; 16.3A5; 1F5; EJ16; EJ30; EL32; FLJ38134; FLJ92039; G344; HRF20; MAC-IP; MACIF; MEM43; MGC2354; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; p18-20; Protectin
分子量

15-20 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD59 Protein, Human (Biotinylated, HEK293, His-Avi)
目录号:
HY-P78906
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