FLRT2 蛋白, Human (HEK293, His)

FLRT2 protein is involved in cell-cell adhesion, migration, and axonal guidance through various interactions. It promotes adhesion by binding to ADGRL3 and potentially other sloth proteins. FLRT2 Protein, Human (HEK293, His) is the recombinant human-derived FLRT2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FLRT2 Protein, Human (HEK293, His) is 504 a.a., with molecular weight of 75-85 kDa.

FLRT2 蛋白在细胞间粘附、细胞迁移和轴突引导中发挥作用，通过各种分子相互作用参与这些过程。它通过与 ADGRL3 和相邻细胞表面上存在的其他潜在的懒虫蛋白结合来促进细胞与细胞的粘附。在大脑发育中，FLRT2 可能通过与 UNC5D 相互作用来促进皮质神经元的迁移。此外，它在轴突生长锥塌陷中发挥作用，并在神经元引导中充当排斥线索，特别是通过其与 UNC5D 和潜在的其他 UNC-5 家族成员的相互作用。FLRT2 参与成纤维细胞生长因子介导的信号级联反应。它对于胚胎发生过程中心脏基底膜的正确组织至关重要，并有助于正常的胚胎心外膜和心脏形态发生。该蛋白质通过富含亮氨酸的重复序列自缔合，形成同源寡聚物。FLRT2 通过其胞外结构域与 FGFR1 和 FGFR2 以及 ADGRL1/LPHN1、ADGRL3、UNC5D、UNC5B（亲和力较低）和 FN1 相互作用，突出了其在细胞过程和发育事件中的多种作用。

Human

HEK293

C-6*His

O43155 (C36-S539)

23768  [NCBI]

CPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSYTPPTPTTSKLPTIPDWDGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGS

75-85 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.