1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Peptide Hormone & Neuropeptides
  4. Growth Hormone/Somatotropin
  5. GH/Somatotropin 蛋白, Human (His)

GH/Somatotropin 蛋白, Human (His)

目录号: HY-P73085
产品使用指南

生长激素 (GH) 在生长控制中发挥着关键作用,刺激肝脏和组织释放胰岛素样生长因子 1 (IGF-1),以促进身体生长。它调节成肌细胞分化和增殖,并对整体有机体发育做出重大贡献。GH/Somatotropin 蛋白, Human (His) 是重组的 GH/生长激素蛋白,由 E. coli 表达,带有 N-His 标签。GH/Somatotropin 蛋白, Human (His) 全长 191 个氨基酸,分子量约为 ~24.7 kDa。

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描述

Growth hormone (GH) plays a key role in growth control, stimulating the release of insulin-like growth factor 1 (IGF-1) from the liver and tissues to promote body growth. It regulates myoblast differentiation and proliferation and contributes significantly to overall organismal development. GH/Somatotropin Protein, Human (His) is the recombinant human-derived GH/Somatotropin protein, expressed by E. coli , with N-His labeled tag. The total length of GH/Somatotropin Protein, Human (His) is 191 a.a., with molecular weight of ~24.7 kDa.

研究背景

生长激素 (GH) 蛋白在生长控制中发挥着关键作用,通过刺激肝脏和其他组织分泌胰岛素样生长因子 1 (IGF-1) 对身体生长发挥主要影响。GH 作为成肌细胞分化和增殖的有效调节剂,对生物体的整体生长和发育做出了重大贡献。此外,它在增强肌肉和各种组织的氨基酸吸收和促进蛋白质合成方面发挥着至关重要的作用。在结构上,GH以多种形式存在,包括单体、二聚体、三聚体、四聚体和五聚体,无论是二硫键连接还是非共价连接,均聚和异聚组合。此外,GH 可以与 GH 结合蛋白 (GHBP) 或 α2-巨球蛋白复合物形成复合物,强调其多功能的分子相互作用,有助于其在生长调节和组织发育中的多方面作用。

种属

Human

表达系统

E. coli

标签

N-His

蛋白编号

P01241 (F27-F217)

基因 ID
同用名
Somatotropin; GH; GH-N; GH1
氨基酸序列

FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF

分子量

Approximately 24.7 kDa

纯度

Greater than 85% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
GH/Somatotropin Protein, Human (His)
目录号:
HY-P73085
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