Glutathione synthetase/GSS 蛋白, Human (His)

Glutathione synthase/GSS protein catalyzes the ATP-dependent synthesis of glutathione from gamma-glutamylcysteine and glycine. Glutathione synthetase/GSS Protein, Human (His) is the recombinant human-derived Glutathione synthetase/GSS protein, expressed by E. coli , with C-6*His labeled tag. The total length of Glutathione synthetase/GSS Protein, Human (His) is 473 a.a., with molecular weight of ~55.0 kDa.

谷胱甘肽合成酶 (GSS) 蛋白通过以 ATP 依赖性方式催化 γ-谷氨酰半胱氨酸和甘氨酸合成谷胱甘肽，在细胞抗氧化防御中发挥关键作用，这一点已得到多项研究的支持。谷胱甘肽 (GSH) 由 γ-谷氨酰半胱氨酰甘氨酸组成，是需氧细胞中最丰富的细胞内硫醇，其由 GSS 合成对于多种细胞过程至关重要。这些包括保护细胞免受氧化损伤、促进氨基酸转运、解毒外来化合物、维持蛋白质巯基处于还原状态以及充当多种酶的辅助因子。此外，GSS 参与肝细胞中的眼甲酸酯生物合成，强调了其在细胞代谢和氧化还原稳态中的多功能作用。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

C-6*His

P48637 (A2-V474)

2937  [NCBI]

ATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAFLEQTLSSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKILSNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLARNIHVIRRTFEDISEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQYSLQNWEARLLLERSHAAKCPDIATQLAGTKKVQQELSRPGMLEMLLPGQPEAVARLRATFAGLYSLDVGEEGDQAIAEALAAPSRFVLKPQREGGGNNLYGEEMVQALKQLKDSEERASYILMEKIEPEPFENCLLRPGSPARVVQCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV

Approximately 55.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 200 mM NaCl, pH 7.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.