1. 重组蛋白
  2. Receptor Proteins
  3. Growth Hormone R/GHR 蛋白, Rat (HEK293, Fc)

Growth Hormone R/GHR 蛋白, Rat (HEK293, Fc)

目录号: HY-P73088
产品使用指南

生长激素 R/GHR 蛋白是垂体生长激素的受体,通过在配体结合后激活 JAK2/STAT5 途径来调节出生后身体生长。其可溶形式 GHBP 可作为生长激素的血浆库,并可能调节或抑制 GH 信号传导。Growth Hormone R/GHR 蛋白, Rat (HEK293, Fc) 是重组的 生长激素 R/GHR 蛋白,由 HEK293 表达,带有 C-hFc 标签。Growth Hormone R/GHR 蛋白, Rat (HEK293, Fc) 全长 247 个氨基酸,分子量约为 ~66 kDa。

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描述

Growth Hormone R/GHR Protein, a receptor for pituitary growth hormone, regulates postnatal body growth by activating the JAK2/STAT5 pathway upon ligand binding. Its soluble form, GHBP, acts as a plasma reservoir for growth hormone and potentially modulates or inhibits GH signaling. Growth Hormone R/GHR Protein, Rat (HEK293, Fc) is the recombinant rat-derived Growth Hormone R/GHR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Growth Hormone R/GHR Protein, Rat (HEK293, Fc) is 247 a.a., with molecular weight of ~66 kDa.

研究背景

生长激素 R (GHR) 蛋白作为垂体生长激素的受体,在调节产后身体生长中发挥着至关重要的作用。与其配体结合后,GHR 偶联并激活 JAK2/STAT5 信号通路。此外,可溶形式的 GHR,称为 GHBP(生长激素结合蛋白),可作为血浆中生长激素的储存库,并可充当生长激素信号传导的调节剂或抑制剂。GHR 和生长激素之间的动态相互作用强调了其在与身体生长相关的生理过程的复杂调节中的关键作用。

种属

Rat

表达系统

HEK293

标签

C-hFc

蛋白编号

P16310-1 (F19-R265)

基因 ID

25235  [NCBI]

蛋白结构
N-term
GHR (F19-R265)
Accession # P16310-1
hFc
C-term
同用名
Growth hormone receptor; GH receptor GHBP; Ghr
氨基酸序列

MDLWRVFLTLALAVSSDMFPGSGATPATLGKASPVLQRINPSLRESSSGKPRFTKCRSPELETFSCYWTEGDDHNLKVPGSIQLYYARRIAHEWTPEWKECPDYVSAGANSCYFNSSYTSIWIPYCIKLTTNGDLLDEKCFTVDEIVQPDPPIGLNWTLLNISLPGIRGDIQVSWQPPPSADVLKGWIILEYEIQYKEVNETKWKTMSPIWSTSVPLYSLRLDKEHEVRVRSRQRSFEKYSEFSEVLRVTFPQMDTLAACEEDFR

分子量

Approximately 66 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Growth Hormone R/GHR Protein, Rat (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Growth Hormone R/GHR Protein, Rat (HEK293, Fc)
目录号:
HY-P73088
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