2. 重组蛋白
  3. Cytokines and Growth Factors CAR-T related Proteins Receptor Proteins Enzymes & Regulators
  4. EGF Superfamily ErbB3/HER3 Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. EGFR/ErbB family
  6. HER3 蛋白, Rat (HEK293, His)

HER3 蛋白, Rat (HEK293, His)

目录号: HY-P74891
产品使用指南

HER3 是一种关键的酪氨酸蛋白激酶，是神经调节蛋白的重要细胞受体。Neuregulin-1 (NRG1) 激活可促进酪氨酸磷酸化以及与磷脂酰肌醇 3-激酶 p85 亚基的相互作用。CSPG5 也可能激活 HER3。它参与骨髓细胞分化，强调了 HER3 在正常发育和功能的重要细胞过程中的重要作用。HER3 蛋白, Rat (HEK293, His) 是重组的 HER3 蛋白，由 HEK293 表达，带有 C-His 标签。HER3 蛋白, Rat (HEK293, His) 全长 622 个氨基酸，分子量约为 ~112 kDa。

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描述

HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Rat (HEK293, His) is the recombinant rat-derived HER3 protein, expressed by HEK293 , with C-His labeled tag. The total length of HER3 Protein, Rat (HEK293, His) is 622 a.a., with molecular weight of ~112 kDa.
研究背景

HER3 是一种酪氨酸蛋白激酶，是神经调节蛋白的关键细胞表面受体。由神经调节蛋白-1 (NRG1) 激活，配体结合增强酪氨酸残基的磷酸化，并促进其与磷脂酰肌醇 3-激酶 p85 亚基的相互作用。此外，有证据表明 CSPG5 可以激活。HER3 错综复杂地参与骨髓细胞分化的调节，突出了其在对正常发育和功能至关重要的细胞过程中的关键作用。
种属

Rat
表达系统

HEK293
标签

C-His
蛋白编号

G3V6N1/XP_017450189.1 (S20-H641)
基因 ID

29496
蛋白结构
N-term
HER3 (S20-H641)
Accession # G3V6N1/XP_017450189.1
His
C-term
同用名
Receptor tyrosine-protein kinase erbB-3; ERBB3; HER3
分子量

Approximately 112 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

HER3 Protein, Rat (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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