1. 重组蛋白
  2. CD Antigens Receptor Proteins
  3. Macrophage CD Proteins Stem Cell CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  4. ICAM-1/CD54 Immunoglobulin-like Cell Adhesion Molecules
  5. Intercellular Adhesion Molecule 1 (ICAM-1)
  6. ICAM-1/CD54 蛋白, Human (453a.a, HEK293, His)

ICAM-1/CD54 蛋白, Human (453a.a, HEK293, His)

目录号: HY-P72621
COA 产品使用指南

ICAM-1/CD54 蛋白在细胞相互作用中发挥着至关重要的作用,充当白细胞粘附蛋白 LFA-1 的配体。它通过 ARHGEF26/SGEF 和 RHOG 激活促进内皮顶杯的组装,从而促进白细胞跨内皮迁移。ICAM-1/CD54 蛋白, Human (453a.a, HEK293, His) 是重组的 ICAM-1/CD54 蛋白,由 HEK293 表达,带有 C-6*His 标签。ICAM-1/CD54 蛋白, Human (453a.a, HEK293, His) 全长 453 个氨基酸,分子量约为 ~88 kDa。

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10 μg ¥800 In-stock
50 μg ¥2200 In-stock
100 μg   询价  

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描述

The ICAM-1/CD54 protein plays a crucial role in cell interactions, acting as a ligand for the leukocyte adhesion protein LFA-1. It promotes leukocyte transendothelial migration by promoting the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. ICAM-1/CD54 Protein, Human (453a.a, HEK293, His) is the recombinant human-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ICAM-1/CD54 Protein, Human (453a.a, HEK293, His) is 453 a.a., with molecular weight of ~88 kDa.

研究背景

ICAM-1/CD54 蛋白在细胞相互作用中发挥着重要作用,充当白细胞粘附蛋白 LFA-1(整合素 α-L/β-2)的配体。特别值得注意的是它在白细胞跨内皮迁移过程中的作用,其中与 ICAM-1 的结合通过激活 ARHGEF26/SGEF 和 RHOG 促进内皮顶杯的组装。在微生物感染的情况下,ICAM-1 还充当主要受体组鼻病毒 AB 衣壳蛋白的受体,突显其在免疫反应和病原体识别中的多功能参与。这种双重功能强调了 ICAM-1 在介导对免疫调节和宿主防御至关重要的多种细胞过程中的重要性。

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

P05362 (Q28-E480)

基因 ID
蛋白结构
N-term
ICAM-1 (Q28-E480)
Accession # P05362
6*His
C-term
同用名
Intercellular Adhesion Molecule 1; ICAM-1; Major Group Rhinovirus Receptor; CD54; ICAM1
氨基酸序列

QTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYE

分子量

Approximately 88 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
ICAM-1/CD54 Protein, Human (453a.a, HEK293, His)
目录号:
HY-P72621
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