NrdD 蛋白, E.coli (His)

The NrdD protein plays a key role in cellular processes by catalyzing the conversion of ribonucleotides into deoxyribonucleotides, an essential component required for DNA synthesis and repair. Various studies have demonstrated that NrdD contributes to the maintenance and replication of genetic material by promoting the conversion of ribonucleotides into their deoxyribonucleotide counterparts through its enzymatic activity. NrdD Protein, E.coli (His) is the recombinant E. coli-derived NrdD protein, expressed by E. coli , with N-His labeled tag. The total length of NrdD Protein, E.coli (His) is 712 a.a., with molecular weight of ~84.0 kDa.

NrdD 是一种酶，通过催化核糖核苷酸转化为脱氧核糖核苷酸，在核苷酸代谢中发挥至关重要的作用。这种酶活性对于细胞内的 DNA 合成和修复过程至关重要。NrdD 有助于 DNA 准确有效复制所需的脱氧核糖核苷酸库的平衡。该酶能够还原四种常见核糖核苷三磷酸中的每一种，强调了其在修饰一系列核苷酸底物方面的多功能性。参考文献强调了 NrdD 在核苷酸生物合成中的核心作用，强调了它在提供 DNA 合成和维持所需前体方面的重要性，而 DNA 是各种细胞过程的基础。

E.coli

E. coli

N-His

P28903 (1M-712G)

948755  [NCBI]

MTPHVMKRDGCKVPFKSERIKEAILRAAKAAEVDDADYCATVAAVVSEQMQGRNQVDINEIQTAVENQLMSGPYKQLARAYIEYRHDRDIEREKRGRLNQEIRGLVEQTNASLLNENANKDSKVIPTQRDLLAGIVAKHYARQHLLPRDVVQAHERGDIHYHDLDYSPFFPMFNCMLIDLKGMLTQGFKMGNAEIEPPKSISTATAVTAQIIAQVASHIYGGTTINRIDEVLAPFVTASYNKHRKTAEEWNIPDAEGYANSRTIKECYDAFQSLEYEVNTLHTANGQTPFVTFGFGLGTSWESRLIQESILRNRIAGLGKNRKTAVFPKLVFAIRDGLNHKKGDPNYDIKQLALECASKRMYPDILNYDQVVKVTGSFKTPMGCRSFLGVWENENGEQIHDGRNNLGVISLNLPRIALEAKGDEATFWKLLDERLVLARKALMTRIARLEGVKARVAPILYMEGACGVRLNADDDVSEIFKNGRASISLGYIGIHETINALFGGEHVYDNEQLRAKGIAIVERLRQAVDQWKEETGYGFSLYSTPSENLCDRFCRLDTAEFGVVPGVTDKGYYTNSFHLDVEKKVNPYDKIDFEAPYPPLANGGFICYGEYPNIQHNLKALEDVWDYSYQHVPYYGTNTPIDECYECGFTGEFECTSKGFTCPKCGNHDASRVSVTRRVCGYLGSPDARPFNAGKQEEVKRRVKHLGNGQIG

Approximately 84.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.