2. 重组蛋白
  3. Enzymes & Regulators
  4. Hydrolases (EC 3)
  5. PCSK6 蛋白, Human (His)

PCSK6 蛋白, Human (His)

目录号: HY-P700617
产品使用指南

PCSK6 蛋白是一种丝氨酸内切蛋白酶，通过在配对碱性氨基酸位点进行切割，特别识别 RXXX[KR]R 共有基序，在前蛋白加工中发挥关键作用。其功能可能涉及组成型分泌途径，在神经内分泌和非神经内分泌组织中具有独特且有限的分布。PCSK6 蛋白, Human (His) 是重组的 PCSK6 蛋白，由 E. coli 表达，带有 C-6*His 标签。PCSK6 蛋白, Human (His) 全长 110 个氨基酸，分子量为 19.4 kDa。

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 μg   询价  
100 μg   询价  

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描述

The PCSK6 protein is a serine endoprotease that plays a key role in preprotein processing by cleavage at sites with paired basic amino acids, specifically recognizing the RXXX[KR]R consensus motif. Its function may be involved in the constitutive secretory pathway, with a unique and limited distribution in neuroendocrine and non-neuroendocrine tissues. PCSK6 Protein, Human (His) is the recombinant human-derived PCSK6 protein, expressed by E. coli , with C-6*His labeled tag. The total length of PCSK6 Protein, Human (His) is 110 a.a., with molecular weight of 19.4 kDa.
研究背景

PCSK6 蛋白是一种丝氨酸内切蛋白酶，通过在以配对碱性氨基酸为特征的位点进行切割，特别识别 RXXX[KR]R 共有基序，在多种前蛋白的加工中发挥着关键作用。其功能参与可能与组成型分泌途径有关，在神经内分泌和非神经内分泌组织中表现出独特且有限的分布。该酶在特定基序处精确切割底物的能力凸显了其在各种细胞环境中前蛋白的调节加工中的重要性。
种属

Human
表达系统

E. coli
标签

C-6*His
蛋白编号

P29122 (R860-G969)
基因 ID
蛋白结构
N-term
PCSK6 (R860-G969)
Accession # P29122
6*His
C-term
同用名
proprotein convertase subtilisin/kexin type 6; PACE4, paired basic amino acid cleaving system 4; SPC4; subtilisin like proprotein convertase 4; subtilisin like protease; subtilisin/kexin like protease PACE4;
氨基酸序列

REECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG

分子量

19.4 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

PCSK6 Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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