TRPV3 蛋白, Human (Cell-Free, His, Flag)

The TRPV3 protein is a putative receptor-activated calcium channel that responds to warm temperatures and exhibits increased activity at harmful temperatures above 39 degrees Celsius. It negatively regulates hair growth by inhibiting keratinocyte proliferation, inducing apoptosis, and causing premature degeneration of hair follicles. TRPV3 Protein, Human (Cell-Free, His, Flag) is the recombinant human-derived TRPV3 protein, expressed by E. coli Cell-free , with N-10*His, N-Flag labeled tag. The total length of TRPV3 Protein, Human (Cell-Free, His, Flag) is 790 a.a., with molecular weight of 93.1 kDa.

TRPV3 被认为是一种假定的受体激活的非选择性钙渗透性阳离子通道，对无害（温暖）的温度做出反应，并在超过 39 摄氏度的有害温度下表现出更高的活性。该通道表现出外向整流作用，并被认为与 TRPV1 相关，可能影响其活性。从功能上来说，TRPV3 是毛发生长和周期的负调节因子，因为它的信号传导抑制毛囊中角质形成细胞的增殖，诱导细胞凋亡，并导致毛囊过早退化（退行期）。与 TRPV1 形成异聚通道的可能性进一步强调了它在热感觉和细胞过程中的作用。TRPV3 与 TRPV1 的相互作用强调了它在调节多种生理反应中的潜在参与。

Human

E. coli Cell-free

N-10*His;N-Flag

Q8NET8 (M1-V790)

162514

MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEVEEFPETSV

93.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.