VEGF165 蛋白, Human (HEK293, StrepⅡ, His)

VEGF165 Protein is a subtype of Vascular Endothelial Growth Factor A (VEGF-A). VEGF-A is a key member of the VEGF family of cytokines that can promote neovascularization and increase vascular permeability. VEGF165 Protein, Human (HEK293, Strep, His) is the recombinant human-derived VEGF165, expressed by HEK293, with Strep, His labeled tag.

VEGF165 是血管内皮生长因子 A (VEGF-A) 的一个亚型。VEGF-A 是血管内皮生长因子 (VEGF) 家族的重要成员，其他成员包括 VEGF-B、-C、-D 和 PGF。VEGF-A 参与血管生成、血管发生和内皮细胞生长，诱导内皮细胞增殖、促进细胞迁移、抑制细胞凋亡并诱导血管通透。VEGF-A 与 FLT1/VEGFR1 和 KDR/VEGFR2 受体、硫酸乙酰肝素和肝素结合。VEGF-A 还与 NRP1 结合，启动运动神经元轴突引导和细胞体迁移所需的信号通路，包括胚胎发育过程中面部运动神经元从菱形 4 到菱形 6 的尾部迁移。VEGF165 可能由肿瘤细胞分泌，以高亲和力与 VEGFR-1 和 VEGFR-2 受体结合^{[1][2][3][4][5][6][7][8]}。

Human

HEK293

C-StrepⅡ;His

P15692 (A27-R191)

/

Partial

<1 EU/μg, determined by LAL method.

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