2. Immunology/Inflammation
  3. Complement System
  4. Riliprubart

Riliprubart  (Synonyms: SAR 445088)

目录号: HY-P990091 纯度: 99.90%
COA 技术支持

Riliprubart (SAR 445088) 是一种抗 C1s 人源化 IgG4 单克隆抗体，可抑制经典补体系统近端部分激活的 C1s。Riliprubart 选择性抑制活化的 C1，并阻止 C1 对其底物 C4 和 C2 的酶促作用，从而抑制经典途径 C3 转化酶 C4b2a 的形成。Riliprubart 可用于研究系统性红斑狼疮等补体介导的疾病。Riliprubart 的同型对照可参考 Human IgG4 (S228P) kappa, Isotype Control (HY-P99003)。

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CAS No. : 2756228-76-7

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规格 价格 是否有货 数量
1 mg ￥1400
In-stock
2 mg ￥2200
In-stock
5 mg ￥4200
In-stock
10 mg ￥6700
In-stock
50 mg   询价  
100 mg   询价  

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Riliprubart 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Riliprubart (SAR 445088) is an anti-C1s humanized IgG4 monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system. Riliprubart selectively inhibits activated C1s and prevents the enzymatic action of C1 on its substrates C4 and C2, thus inhibiting the formation of the classical pathway C3 convertase, C4b2a. Riliprubart can be used to study complement-mediated diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003)[1].

同型

Human IgG4 kappa
推荐同型对照抗体
IC50 & Target

C1s
Clinical Trial
基因 ID

716  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

145.52 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized C1s/Complement component C1s Protein, Human (HEK293, His, HY-P700696) can bind Riliprubart. The EC50 for this effect is 3.783 ng/mL.
纯度 & 产品资料

纯度: 99.90%

COA (265 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Riliprubart 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Riliprubart2756228-76-7SAR 445088SAR445088SAR-445088Complement SystemC1scomplement systemC4C2C3C4b2aInhibitorinhibitorinhibit

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